Area of research
Molecular Biology · Oncology
Research interest
Research interests include Cancer-related Molecular Pathways, DNA Repair Mechanisms, Effects of Radiation Exposure, and Metabolomics and Mass Spectrometry Studies.
Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in <i>Apc</i><sup>1638N/+</sup> mice.
Radiation Quality-Dependent Progressive Increase in Oxidative DNA Damage and Intestinal Tumorigenesis in <i>Apc</i><sup>1638N/+</sup> Mice.
cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice.
Sex Differences in Urinary Metabolite Profiles between Survivors and Non-Survivors of Radiation-induced Lung Injury in the C57L/J Murine Model.
Elevated SASP Factors, Reduced Antioxidant Enzymes, and Increased Tumor Susceptibility in Space Radiation-Exposed <i>Apc</i><sup>Min/+</sup> Mice.
Multicentered Biospecimen Analyses after 4 Gy Sublethal Total Body Irradiation in Rhesus Macaques.
TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use.
8-OxodG: A Potential Biomarker for Chronic Oxidative Stress Induced by High-LET Radiation.
Impact of Partial Body Shielding from Very High Dose Rates on Untargeted Metabolomics in Biodosimetry.
Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in <i>Apc</i><sup>Min/+</sup> Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis.
Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure.
Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis.
FAILLA MEMORIAL LECTURE How We Got Here: One Laboratory's Odyssey in the Field of Radiation-Inducible Genes.
Galactic cosmic ray simulation at the NASA space radiation laboratory - Progress, challenges and recommendations on mixed-field effects.
High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development.
Biomarker integration for improved biodosimetry of mixed neutron + photon exposures.
Simulated galactic cosmic radiation (GCR)-induced expression of Spp1 coincide with mammary ductal cell proliferation and preneoplastic changes in Apc<sup>Min/+</sup> mouse.
Variable Dose Rates in Realistic Radiation Exposures: Effects on Small Molecule Markers of Ionizing Radiation in the Murine Model.
Expression of Stem Cell Markers in High-LET Space Radiation-Induced Intestinal Tumors in <i>Apc</i><sup>1638N/+</sup> Mouse Intestine.
Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure.
Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.
White-Nose Syndrome Disrupts the Splenic Lipidome of Little Brown Bats (<i>Myotis lucifugus</i>) at Early Disease Stages.
GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis.
Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome.
Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow.
Biofluid Metabolomics and Lipidomics of Mice Exposed to External Very High-Dose Rate Radiation.
Countermeasure development against space radiation-induced gastrointestinal carcinogenesis: Current and future perspectives.
A high-throughput and highly automated genotoxicity screening assay.
Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry.
Predominant contribution of the dose received from constituent heavy-ions in the induction of gastrointestinal tumorigenesis after simulated space radiation exposure.