Area of research
Genetics · Molecular Medicine
Research interest
Research interests include Bacterial Genetics and Biotechnology, Antibiotic Resistance in Bacteria, RNA and protein synthesis mechanisms, and Microbial Natural Products and Biosynthesis.
SyntheMol-RL: a flexible reinforcement learning framework for designing easily synthesizable antibiotics.
Evaluation of Azithromycin-Bicarbonate against Multidrug-Resistant Pathogens in Topical Murine Models of Infection.
Exploiting the fitness cost of metallo-β-lactamase expression can overcome antibiotic resistance in bacterial pathogens.
Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic
Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic.
SyntheMol-RL: a flexible reinforcement learning framework for designing novel and synthesizable antibiotics
Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH.
Identifying Modulators of the Post-Antibiotic Effect.
Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library.
Author Correction: Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic.
A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris
Identifying Modulators of the Post-Antibiotic Effect
High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics.
Cryo-EM analysis of <i>S. aureus</i> TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance.
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database.
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
Inhibiting fatty acid synthesis overcomes colistin resistance.
A standardized nomenclature for resistance-modifying agents in the Comprehensive Antibiotic Resistance Database.
A Bifunctional Spray Coating Reduces Contamination on Surfaces by Repelling and Killing Pathogens.
Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics.
Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal <i>Salmonella</i> (iNTS).
The fitness cost of metallo-β-lactamase expression is a potential target for new therapeutic approaches to carbapenem resistance
A genetic platform to investigate the functions of bacterial drug efflux pumps.
Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant.
Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery.
Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli.
Central metabolism is a key player in
<i>E. coli</i>
biofilm stimulation by sub-MIC antibiotics
Polynuclear ruthenium complexes are effective antibiotics against
<i>Pseudomonas aeruginosa</i>
Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane.