← back to search

Jonathan A. Javitch

Columbia University Irving Medical Center · US
Area of research
Cellular and Molecular Neuroscience · Molecular Biology
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuroscience and Neuropharmacology Research, Neurotransmitter Receptor Influence on Behavior, and Neuropeptides and Animal Physiology.
h-index
99
citations
32,460
works
427
NIH funding
primary concept
email

Recent publications

Promiscuous G-protein activation by the calcium-sensing receptor
Nature 2024cited by 28position: middledoi
Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons
eLife 2023cited by 30position: middledoi
Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain
Neuropsychopharmacology 2023cited by 6position: middledoi
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision
Cell 2022cited by 107position: lastdoi
Single-molecule FRET imaging of GPCR dimers in living cells
Nature Methods 2021cited by 208position: lastdoi
Single-molecule FRET imaging of GPCR dimers in living cells.
2021cited by 156position: selecteddoi
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects
Journal of Medicinal Chemistry 2021cited by 74position: middledoi
A novel luminescence-based β-arrestin recruitment assay for unmodified receptors.
2021cited by 19position: selecteddoi
Structure of human GABAB receptor in an inactive state
Nature 2020cited by 98position: middledoi
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells
Science Advances 2020cited by 70position: middledoi
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores
Proceedings of the National Academy of Sciences 2020cited by 68position: middledoi
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
2020cited by 63position: selecteddoi
Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.
2020cited by 57position: selecteddoi
Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists
Biochemical Pharmacology 2020cited by 55position: middledoi
Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter
ACS Chemical Neuroscience 2020cited by 22position: middledoi
Author Correction: Structure of human GABAB receptor in an inactive state
Nature 2020cited by 5position: middledoi
7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
ACS Central Science 2019cited by 204position: selecteddoi
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor
Journal of the American Chemical Society 2019cited by 75position: middledoi
Quantifying secondary transport at single-molecule resolution
Nature 2019cited by 68position: middledoi
Do Toxic Synthetic Cannabinoid Receptor Agonists Have Signature in Vitro Activity Profiles? A Case Study of AMB-FUBINACA
ACS Chemical Neuroscience 2019cited by 63position: middledoi
Quantifying secondary transport at single-molecule resolution.
2019cited by 55position: selecteddoi
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
Nature Communications 2018cited by 56position: middledoi
Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi:
2018cited by 0position: selected
Treatment resistant depression: A multi-scale, systems biology approach
Neuroscience & Biobehavioral Reviews 2017cited by 446position: middledoi
Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
Nature 2017cited by 357position: middledoi
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Neuropsychopharmacology 2017cited by 275position: middledoi
Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT
Neuron 2017cited by 97position: middledoi
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist
Journal of the American Chemical Society 2017cited by 83position: middledoi
Synthetic and Receptor Signaling Explorations of the <i>Mitragyna</i> Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
Journal of the American Chemical Society 2016cited by 313position: middledoi
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
Nature Communications 2016cited by 128position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Scott C. Blanchard · St. Jude Children's Research Hospital8 papers (2017–2022)Lei Shi · National Institute on Drug Abuse7 papers (2012–2022)Daniel S. Terry · St. Jude Children's Research Hospital6 papers (2017–2022)Harel Weinstein · Cornell University6 papers (2012–2018)Dalibor Sameš · Columbia University5 papers (2016–2021)Prashant Donthamsetti · Vanderbilt University5 papers (2012–2019)Matthias Quick · Columbia University5 papers (2012–2019)Wesley B. Asher · Columbia University5 papers (2020–2024)Zhou Zhou · Hebei Medical University4 papers (2017–2021)Jonathan A. Javitch · Chimie et Biologie des Membranes et des Nanoobjects4 papers (2020–2021)Jamie J. Manning · Columbia University3 papers (2019–2024)Mayako Michino · Cancer Research Center3 papers (2012–2014)Thijs Beuming · Schrodinger (United States)3 papers (2012–2014)Signe Mathiasen · Columbia University3 papers (2017–2021)Amy Hauck Newman · Target (United States)3 papers (2012–2020)Andrew C. Kruegel · Columbia University2 papers (2016–2017)Avik Kumar Pati · St. Jude Children's Research Hospital2 papers (2020–2021)Ehud Y. Isacoff · University of California, Berkeley2 papers (2017–2019) · 2 papers (2016–2021)Mark S. Sonders · Columbia University2 papers (2016–2017)