Area of research
Cell Biology · Pulmonary and Respiratory Medicine
Research interest
Research focused on Unfolded protein response and Calreticulin, with related work in Endoplasmic reticulum, XBP1, Microviscosity. Notable publications include 'Paneth cells as a site of origin for intestinal inflammation', 'An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles', and 'Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells'.
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
GDF15 antagonism limits severe heart failure and prevents cardiac cachexia
Leveraging the pleural space for anticancer therapies in pleural mesothelioma
Convergent evolution of somatic escape variants in <i>SERPINA1</i> in the liver in alpha-1 anti-trypsin deficiency
Scientific Business Abstracts
Z-α <sub>1</sub> -antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state
Seventh BHD international symposium: recent scientific and clinical advancement
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis
An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles
hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells
Paneth cells as a site of origin for intestinal inflammation