Area of research
Neurology · Cellular and Molecular Neuroscience
Research interest
Research focused on Synaptic vesicle and Binding site, with related work in Receptor, Endocytosis, Neurotoxin. Notable publications include 'N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A', 'Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E', and 'Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A'.
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry
Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain