Area of research
Cellular and Molecular Neuroscience · Physiology
Research interest
Research interests include Nerve injury and regeneration, Alzheimer's disease research and treatments, Cholinesterase and Neurodegenerative Diseases, and Neuroinflammation and Neurodegeneration Mechanisms.
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
Activity‐dependent dysfunctional gene expression patterns are normalized by <i>in vivo</i> treatment of late‐stage Aβ pathology mice with a TrkB/C small molecule ligand
Nerve Growth Factor Pathobiology During the Progression of Alzheimer’s Disease
P3‐212: A SMALL MOLECULE TRKB/TRKC NEUROTROPHIN RECEPTOR CO‐ACTIVATOR PREVENTS SYNAPTIC IMPAIRMENT IN AN AD MOUSE MODEL
Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking
The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation
A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPPL/S Transgenic Mice
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease
A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease
A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model
Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
A small molecule p75NTR ligand protects neurogenesis after traumatic brain injury
S4–02–04: Targeting Alzheimer's disease–related mechanisms with p75 ligands
A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome
Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor
PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease