Area of research
Pathology and Forensic Medicine · Plant Science
Research interest
Research topics from publications: Preparation and characterization of epigallocatechin gallate, ascorbic acid, gelatin, chitosan nanoparticles and their beneficial effect on wound healing of diabetic mice; Hypoglycemic and lipid lowering effects of theaflavins in high-fat diet-induced obese mice; Anti-hyperuricemic effects of three theaflavins isolated from black tea in hyperuricemic mice. Representative work: ). All groups were studied for 9 weeks continuously. The levels of serum glucose, insulin, TC, TG, LDL and HLD in the plasma, lipid accumulation in the liver, and injury of the liver were investigated. In addition, the effects of TFs and their monomers on the SIRT6/AMPK/SREBP-1/FASN pathway were also evaluated. The results showed that oral administration of TFs, TF1, TF2a and TF3 not only dramatically suppressed weight gain, reduced blood glucose level, and ameliorated insulin resistance but also obviously lowered the levels of serum TC, TG and LDL, suppressed the activities of ALT and AST, and ameliorated hepatic damage in mice fed a HFD when compared to the HFD group. Western blot analysis Theaflavins are characteristic ingredients of black tea which are correlated with their qualities and functions. The study aimed to evaluate the effects and mechanism of major theaflavin monomers reducing serum uric acid (SUA) in hyperuricemic mice. Three theaflavin monomers of TF, TFDG and TF-3-G were isolated and purified from black tea. The results showed that they have obvious SUA-lowering effect on hyperuricemic mice. They suppressed the activities of ADA and XOD, down-regulated the genes and proteins expression of GLUT9 and URAT1, up-regulated the gene and protein expression of OAT1 and the genes expression of ABCG2, OCTN1, OCT1/2, and OAT2. They could also decrease serum BUN and Cr va
Hypoglycemic and lipid lowering effects of theaflavins in high-fat diet-induced obese mice
Preparation and characterization of epigallocatechin gallate, ascorbic acid, gelatin, chitosan nanoparticles and their beneficial effect on wound healing of diabetic mice
Anti-hyperuricemic effects of three theaflavins isolated from black tea in hyperuricemic mice