Area of research
Infectious Diseases · Epidemiology
Research interest
Research focused on Tuberculosis and Extensively drug-resistant tuberculosis, with related work in Sputum, Intensive care medicine, Bedaquiline. Notable publications include 'The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis', 'Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial', and 'Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis'.
Factors associated with tuberculosis treatment initiation among bacteriologically negative individuals evaluated for tuberculosis: An individual patient data meta-analysis
Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests: rationale and guidance for future research
Evaluation of the Xpert MTB Host Response assay for the triage of patients with presumed pulmonary tuberculosis: a prospective diagnostic accuracy study in Viet Nam, India, the Philippines, Uganda, and South Africa
Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study
Diagnostic Accuracy of Tuberculosis Screening Tests in a Prospective Multinational Cohort: Chest Radiography With Computer-Aided Detection, Xpert Tuberculosis Host Response, and C-Reactive Protein
A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis
In-home TB Testing Using GeneXpert Edge is Acceptable, Feasible, and Improves the Proportion of Symptomatic Household Contacts Tested for TB: A Proof-of-Concept Study
Critical assessment of infants born to mothers with drug resistant tuberculosis
Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study
Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data
Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13
Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis
Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights
Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis
Development and clinical evaluation of a new multiplex PCR assay for a simultaneous diagnosis of tuberculous and nontuberculous mycobacteria
Health care seeking patterns of rifampicin-resistant tuberculosis patients in Harare, Zimbabwe: A prospective cohort study
The child ecosystem and childhood pulmonary tuberculosis: A South African perspective
Systematic review of mutations associated with resistance to the new and repurposed<i>Mycobacterium tuberculosis</i>drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid
Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis
The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis
Bedaquiline Microheteroresistance after Cessation of Tuberculosis Treatment
Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation
Point of care diagnostics for tuberculosis
Evaluation of the airway microbiome in nontuberculous mycobacteria disease
The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates<i>Mycobacterium tuberculosis–</i>Specific Host Immunity Through the Glucocorticoid Receptor
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study
Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance