Area of research
Gastroenterology · Physiology
Research interest
Research focused on Visceral pain and Nociception, with related work in Dorsal root ganglion, Irritable bowel syndrome, Nociceptor. Notable publications include 'α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA B receptors', 'Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity', and 'Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain'.
Parasites trigger epithelial cell crosstalk to drive gut–brain signalling
Topological segregation of stress sensors along the gut crypt–villus axis
Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension
Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity
Contribution of membrane receptor signalling to chronic visceral pain
Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain
α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA<sub>B</sub>receptors