Area of research
Public Health, Environmental and Occupational Health · Hematology
Research interest
Research focused on Cancer research and CDKN2A, with related work in Epigenetics, Ribosomal protein, PRC2. Notable publications include 'Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia', 'Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia', and 'The genetics and molecular biology of T-ALL'.
HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia
Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer
Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer
Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping
<i>HEATR3</i> variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia
The ins and outs of serine and glycine metabolism in cancer
14q32 rearrangements deregulating <i>BCL11B </i>mark a distinct subgroup of T and myeloid immature acute leukemia
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia
Hallmarks of ribosomopathies
Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
Cancer Biogenesis in Ribosomopathies
Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia
The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
The genetics and molecular biology of T-ALL
The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types
The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
Synergistic antileukemic therapies in <i>NOTCH1</i> -induced T-ALL
Ribosomopathies and the paradox of cellular hypo- to hyperproliferation
Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia
Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia
NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes