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Sebastian Brabetz

Champions Oncology (United States) · US
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Area of research
Genetics · Cancer Research
Research interest
Research interests include Glioma Diagnosis and Treatment, Cancer Genomics and Diagnostics, Neuroblastoma Research and Treatments, and Cancer Immunotherapy and Biomarkers.
h-index
19
citations
5,043
works
75
NIH funding
primary concept
email

Recent publications

Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours
Genome Medicine 2023cited by 14position: middledoi
Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma
Neuro-Oncology Advances 2022cited by 8position: middledoi
Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours
bioRxiv (Cold Spring Harbor Laboratory) 2022cited by 1position: middledoi
Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion
Advanced Science 2021cited by 33position: middledoi
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Cancer Research 2020cited by 62position: middledoi
The molecular landscape of ETMR at diagnosis and relapse
Nature 2019cited by 144position: middledoi
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis
Nature Communications 2019cited by 109position: middledoi
MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children’s Oncology Group ACNS0332 Trial
American Journal of Neuroradiology 2019cited by 20position: middledoi
MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY
Neuro-Oncology 2019cited by 0position: middledoi
THER-02. TARGETING DNA DAMAGE REPAIR IN MYC-DRIVEN PEDIATRIC BRAIN TUMORS
Neuro-Oncology 2019cited by 0position: middledoi
PDTM-17. MiR-126, miR-369-5p AND miR-487b DRIVE PEDIATRIC GLIOBLASTOMA INVASION VIA KCNA1
Neuro-Oncology 2019cited by 0position: middledoi
The landscape of genomic alterations across childhood cancers
Nature 2018cited by 1,589position: middledoi
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
The Lancet Oncology 2018cited by 393position: middledoi
A biobank of patient-derived pediatric brain tumor models
Nature Medicine 2018cited by 185position: firstdoi
Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling
Cancer Cell 2018cited by 135position: middledoi
Author Correction: The landscape of genomic alterations across childhood cancers
Nature 2018cited by 28position: middledoi
EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS
Neuro-Oncology 2018cited by 2position: middledoi
MBRS-33. RNA-SEQUENCING OF MEDULLOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS ENABLES IDENTIFICATION OF BOTH TUMOR AND MICROENVIRONMENT SPECIFIC BIOMARKERS
Neuro-Oncology 2018cited by 0position: middledoi
EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)
Neuro-Oncology 2018cited by 0position: middledoi
PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH
Neuro-Oncology 2018cited by 0position: firstdoi
EMBR-01. MOLECULAR AND CLINICAL HETEROGENEITY IN HISTOLOGICALLY-DIAGNOSED CNS-PNET PATIENTS PROSPECTIVELY TREATED AS A SINGLE ENTITY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL
Neuro-Oncology 2018cited by 0position: middledoi
Abstract 4124: YAP1 fusion proteins mediate oncogenic activity in ependymoma via interaction with TEAD transcription factors
Cancer Research 2018cited by 0position: middledoi
Abstract 3172: Targeting genomic instability in embryonal tumors with multilayered rosettes (ETMR)
Cancer Research 2018cited by 0position: middledoi
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
Cancer Research 2017cited by 128position: middledoi
Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients
Neuro-Oncology 2017cited by 49position: middledoi
PDCT-05. MOLECULAR DIAGNOSTICS REVEAL 60% HIGHER SURVIVAL FOR MOLECULARLY-VERIFIED VERSUS HISTOPATHOLOGICALLY-DIAGNOSED PEDIATRIC SUPRATENTORIAL CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS AND PINEOBLASTOMAS; A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL
Neuro-Oncology 2017cited by 2position: middledoi
EPND-13. YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE
Neuro-Oncology 2017cited by 1position: middledoi
TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS
Neuro-Oncology 2017cited by 0position: firstdoi
Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors
Cancer Research 2017cited by 0position: firstdoi
CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS
Neuro-Oncology 2017cited by 0position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Stefan M. Pfister · Université du Québec32 papers (2015–2023)Marcel Kool · European Bioinformatics Institute32 papers (2015–2023)David Jones · Mayo Clinic in Florida13 papers (2015–2023)Till Milde · Children's Cancer Center13 papers (2015–2018)Andrey Korshunov · German Cancer Research Center11 papers (2016–2022)James M. Olson · InSightec (Israel)11 papers (2015–2019)Robert J. Wechsler‐Reya · Columbia University Irving Medical Center11 papers (2015–2018)Olaf Witt · St. Jude Children's Research Hospital10 papers (2016–2022)Norman Mack · German Cancer Research Center9 papers (2016–2022)Xiao‐Nan Li · Lanzhou University9 papers (2016–2021)David Capper · German Cancer Research Center8 papers (2016–2019)Huriye Seker‐Cin · Heidelberg University8 papers (2015–2017)Florian Selt · German Cancer Research Center8 papers (2016–2018)Jessica M. Rusert · Discovery Institute7 papers (2015–2018)Susanne Gröbner · German Cancer Research Center6 papers (2015–2019)Sarah Leary · Neurological Surgery6 papers (2016–2018)Lukas Chávez · Children’s Institute6 papers (2017–2019)Sander Lambo · Hopp Children's Cancer Center Heidelberg6 papers (2018–2023)Natalie Jäger · Hopp Children's Cancer Center Heidelberg5 papers (2018–2023)Kristian W. Pajtler · German Cancer Research Center5 papers (2016–2018)
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