Area of research
Molecular Biology · Neurology
Research interest
Research focused on Necroptosis and Proteases, with related work in Cell biology, Protease, Transcription factor. Notable publications include 'SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species', 'Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential', and 'Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies'.
The N-end rule pathway regulates ER stress-induced clusterin release to the cytosol where it directs misfolded proteins for degradation
The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein
A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death
Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice