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Jasper van der Lugt

Princess Máxima Center ·
🔎 Find collaborators in Genetics · Neurology →
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Area of research
Genetics · Neurology
Research interest
Research interests include Glioma Diagnosis and Treatment, Neuroblastoma Research and Treatments, HIV/AIDS drug development and treatment, and Virus-based gene therapy research.
h-index
24
citations
2,327
works
147
NIH funding
primary concept
Medicine
email

Recent publications

Dual targeting of <i>CD155</i>/<i>TIGIT</i> and <i>PD-L1</i>/<i>PD-1</i> immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma
Neuro-Oncology Advances 2025cited by 3position: middledoi
Molecular and clinical stratification of astroblastomas: Three distinct fusion-defined groups informing risk-adapted treatment strategies
Neuro-Oncology 2025cited by 3position: middledoi
Growth recovery in patients with <i>BRAF</i> altered pediatric low-grade gliomas (LGG) after discontinuation of tovorafenib.
Journal of Clinical Oncology 2025cited by 1position: middledoi
CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models
Journal of Clinical Investigation 2025cited by 1position: middledoi
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
Nature Medicine 2024cited by 4position: middledoi
CTNI-09. TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY (R/R) PEDIATRIC LOW-GRADE GLIOMA (PLGG): RESULTS FROM PATIENTS ON A DRUG HOLIDAY (DH) IN THE PHASE 2 FIREFLY-1 TRIAL
Neuro-Oncology 2024cited by 1position: middledoi
LGG-40. TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY PEDIATRIC LOW-GRADE GLIOMA (PLGG): REVERSIBLE DECREASES IN GROWTH VELOCITY IN THE PHASE 2 FIREFLY-1 TRIAL
Neuro-Oncology 2024cited by 1position: middledoi
Dabrafenib plus Trametinib in Pediatric Glioma with <i>BRAF</i> V600 Mutations
New England Journal of Medicine 2023cited by 255position: middledoi
Ultra-fast deep-learned CNS tumour classification during surgery
Nature 2023cited by 184position: middledoi
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
Nature Medicine 2023cited by 169position: middledoi
TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
Cancer Cell 2023cited by 103position: middledoi
Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/Refractory <i>BRAF</i> V600–Mutant Pediatric High-Grade Glioma
Journal of Clinical Oncology 2023cited by 63position: middledoi
Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm
JAMA Network Open 2023cited by 43position: middledoi
A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered
Neuro-Oncology 2023cited by 30position: middledoi
Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology
Neoplasia 2023cited by 14position: lastdoi
Clinical activity of pan-RAF inhibitor tovorafenib in the registrational pediatric low-grade glioma arm of the phase 2 FIREFLY-1 (PNOC026) study.
Journal of Clinical Oncology 2023cited by 13position: middledoi
LGG-09. CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY
Neuro-Oncology 2023cited by 2position: middledoi
CTNI-37. CLINICAL ACTIVITY OF RAF INHIBITOR TOVORAFENIB ACCORDING TO PRIOR MAPK INHIBITOR TREATMENT IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY
Neuro-Oncology 2023cited by 1position: middledoi
Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’
European Journal of Cancer 2022cited by 58position: middledoi
Primary analysis of a phase II trial of dabrafenib plus trametinib (dab + tram) in <i>BRAF</i> V600–mutant pediatric low-grade glioma (pLGG).
Journal of Clinical Oncology 2022cited by 49position: middledoi
CTNI-68. FIREFLY-1 (PNOC026): PHASE 2 STUDY OF PAN-RAF INHIBITOR TOVORAFENIB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RAF-ALTERED RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA OR ADVANCED SOLID TUMORS
Neuro-Oncology 2022cited by 13position: middledoi
FIREFLY-1 (PNOC 026): A phase 2 study to evaluate the safety and efficacy of tovorafenib (DAY101) in pediatric patients with <i>RAF</i>-altered recurrent or progressive low-grade glioma or advanced solid tumors.
Journal of Clinical Oncology 2022cited by 4position: middledoi
Phase I results of the INFORM2 combination study of nivolumab and entinostat in children and adolescents: INFORM2 NivEnt.
Journal of Clinical Oncology 2022cited by 3position: middledoi
RARE-15. Astroblastoma, <i>MN1</i> altered comprises two molecularly and clinically distinct subgroups defined by the fusion partners <i>BEND2</i> and <i>CXXC5</i>
Neuro-Oncology 2022cited by 3position: middledoi
ETMR-06. Molecular and clinical characteristics of CNS tumors with<i>BCOR(L1</i>) fusion/internal tandem duplication
Neuro-Oncology 2022cited by 3position: middledoi
P02.07 Characterization of the tumor immune microenvironment of pediatric posterior fossa A ependymomas
Poster presentations 2021cited by 0position: lastdoi
Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
AIDS Care 2014cited by 93position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Olaf Witt · St. Jude Children's Research Hospital6 papers (2022–2023)Jordan R. Hansford · South Australia Pathology6 papers (2022–2023)Daniel Landi · Duke University4 papers (2022–2025)Darren Hargrave · Great Ormond Street Hospital4 papers (2022–2023)Sarah Leary · Neurological Surgery4 papers (2022–2025)Lindsay Kilburn · Columbia University Irving Medical Center4 papers (2022–2025)Dong‐Anh Khuong‐Quang · McGill University Health Centre4 papers (2022–2025)Karsten Nysom · Hôpital des Enfants3 papers (2023–2025)Patricia Baxter · Baylor College of Medicine3 papers (2022–2023)Simon Bailey · Newcastle University3 papers (2023–2025)Michael C. Cox · Green Circle3 papers (2022–2023)Geoffrey McCowage · Children's Hospital at Westmead3 papers (2022–2023)Angela J. Waanders · Cancer Clinic3 papers (2022–2023)Pablo Hernáiz Driever · German Center for Pediatric and Adolescent Rheumatology3 papers (2023–2025)David S. Ziegler · UNSW Sydney3 papers (2022–2023)Daniel Da Costa · AbbVie (United States)3 papers (2022–2023)Marcel Kool · European Bioinformatics Institute3 papers (2021–2025) · 3 papers (2021–2023)Maria Luisa Garrè · University of Padua2 papers (2022–2023)Sabine Mueller · Philadelphia University2 papers (2023–2023)
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