Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Angiogenesis and VEGF in Cancer, Pulmonary Hypertension Research and Treatments, Pluripotent Stem Cells Research, and Cancer, Hypoxia, and Metabolism.
Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation
Engineered Wnt7a ligands rescue blood–brain barrier and cognitive deficits in a COVID-19 mouse model
Modulation of NOX2 causes obesity-mediated atrial fibrillation
Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility
Physiological Modeling of the Vascularized Human Lung Organoid
Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing
Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism
CX3CR1 + Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26
Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells
Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy
Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC–derived atrial fibrillation model
Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury
Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming
Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19
The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)
Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation
Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues
Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice