Area of research
Molecular Biology · Oncology
Research interest
Research projects in the Statsyuk laboratory use chemistry to illuminate mechanisms of human diseases, and to develop novel therapeutic modalities to treat them. Our research group is highly interdisciplinary and encompasses chemistry, protein & structural biochemistry, enzymology, cell biology, pharmacokinetics, and drug discovery. The research projects are highly collaborative in nature. Our drug discovery efforts focus on developing ultra-selective and ultra-potent drugs that affect only disease tissues but not normal tissues, and therefore have no side effects. Ultra-selectivity is achieved by designing drugs that target specific disease mutations, by targeting specific receptors present in the disease cells, by using ternary pharmacology approaches (i.e. designing drugs that bind the receptor with the help of the disease tissue specific helper proteins), antibody-drug conjugates, natural products, as well as covalent protein and small molecule drugs. Specific projects are as follows (more details can be found in my LinkedIn profile):
AI is a viable alternative to high throughput screening: a 318-target study
Xu, Alexander V. Statsyuk , Brian C. Smith, ACS Chemical Biology, 2020, 15(4):1036-1049
— 2020cited by 0position: selected
Mass Spectrometry, Parker, B.; Goncz, E.; Krist, D.T.; Statsyuk, A.V. ; Nesvizhskii, A.I.; Weiss, E. Proceedings of the National Academy of Sciences, 2019,
— 2019cited by 0position: selected
P.K.; Krist, D.T.; Rice, S.E.; Statsyuk, A.V. Journal of Biological Chemistry 2017, 292 (40):16539-16553.
— 2017cited by 0position: selected
Enzyme. Misra, M.; Kuhn, M.; L ö bel, M.; An, H.; Statsyuk, A.V. ; Sotriffer, C.; Schindelin, H. Structure 2017, 25(7):1120-1129.e3.
— 2017cited by 0position: selected
G.; Rice, S.; Statsyuk, A.V. Chemical Science 2016, 7, 5587-5595.
— 2016cited by 0position: selected
A.C.; Statsyuk, A.V. Journal of the American Chemical Society 2015, 137 (39):12442-12445.
— 2015cited by 0position: selected
Photo-cross-linkers. Krist, D.T.; Statsyuk A.V. Biochemistry 2015, 54 (29), 4411-4414.
— 2015cited by 0position: selected
Kathman, S.G.; Xu, Z.Y.; Statsyuk, A.V. Journal of Medicinal Chemistry 2014, 57 (11), 4969-74.
— 2014cited by 0position: selected
Pathways. An, H.; Statsyuk A.V. Journal of the American Chemical Society 2013, 135 (45), 16948-16962.
— 2013cited by 0position: selected
Pairs. Park, S.; Ntai, I.; Thomas, P.; Konishcheva, E.; Kelleher, N.L.; Statsuk, A.V. Biochemistry 2012, 51(42), 8327-8329.
— 2012cited by 0position: selected
J, Shokat KM. J Am Chem Soc. 2008 Dec 24;130(51):17568-74.
— 2008cited by 0position: selected
Actin is the primary cellular receptor of bistramide A. Statsuk AV , Bai R, Baryza JL, Verma VA, Hamel E, Wender PA, Kozmin SA. Nat Chem Biol. 2005 Dec;1(7):383-8.
— 2005cited by 0position: selected