Area of research
Epidemiology · Pharmacology
Research interest
Research interests include Autophagy in Disease and Therapy, Liver Disease Diagnosis and Treatment, Alcohol Consumption and Health Effects, and Drug-Induced Hepatotoxicity and Protection.
Mitochondrial dynamics, quality control, and mtDNA in alcohol-associated liver disease and liver cancer.
An Update on Animal Models of Alcohol-Associated Liver Disease
Mechanisms of scramblases in regulating hepatic lipoprotein secretion and autophagy
Overlapping Yet Distinct Functions of Vacuole Membrane Protein 1 and Transmembrane Protein 41B in Modulating Hepatic Lipoprotein Secretion and Autophagy
An ER transmembrane protein protects against hepatic ischemia-reperfusion injury by inhibiting ER-phagy and apoptosis?
Role of SQSTM1/p62 in regulating Mallory-Denk body in alcohol-associated liver disease.
Multimodal decoding of human liver regeneration uncovers novel ANXA2+ migratory hepatocytes for wound healing.
High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice.
Eosinophils: a novel therapeutic target to promote liver regeneration in acute liver injury?
Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis
Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.
Loss of hepatic VMP1 trapped VLDL in the bilayer of endoplasmic reticulum membrane
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation
Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis.
Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy.
Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR
Lack of hepatic autophagy promotes severity of liver injury but not steatosis
Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice
Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis
Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)–Mixed Lineage Kinase Domain-Like Protein (MLKL)–Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers
Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy‐Defective Mouse Liver
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice
Role of Intracellular Calcium in Proteasome Inhibitor-Induced Endoplasmic Reticulum Stress, Autophagy, and Cell Death
Targeting autophagy for the treatment of liver diseases