Area of research
Molecular Biology · Genetics
Research interest
Research interests include RNA and protein synthesis mechanisms, RNA modifications and cancer, Bacterial Genetics and Biotechnology, and Bacteriophages and microbial interactions.
A Role for Two Conserved Arginine Residues in Protected Persulfide Transfer by SufE-Dependent SufS Cysteine Desulfurases
The structure of the SufS–SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis
The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning
The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems
The effect of crRNA–target mismatches on cOA-mediated interference by a type III-A CRISPR-Cas system
The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems
Three critical regions of the erythromycin resistance methyltransferase, ErmE, are required for function supporting a model for the interaction of Erm family enzymes with substrate rRNA
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition
Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases
Regulation of cyclic oligoadenylate synthesis by the <i>Staphylococcus epidermidis</i> Cas10-Csm complex
Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues
Mechanism of tRNA-mediated +1 ribosomal frameshifting
Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS
E. coli cysteine desulfurase SufS E96A with a cysteine persulfide intermediate
Molecular determinants for CRISPR RNA maturation in the Cas10–Csm complex and roles for non-Cas nucleases
Defining the mRNA recognition signature of a bacterial toxin protein
Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA
Reorganization of an intersubunit bridge induced by disparate 16S <i>ribosomal ambiguity</i> mutations mimics an EF-Tu-bound state