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Adam S. Sperling

Harvard University · US
Area of research
Hematology · Oncology
Research interest
Research interests include Multiple Myeloma Research and Treatments, Acute Myeloid Leukemia Research, CAR-T cell therapy research, and Myeloproliferative Neoplasms: Diagnosis and Treatment.
h-index
36
citations
6,110
works
333
NIH funding
primary concept
Medicine
email

Recent publications

International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma
Journal of Clinical Oncology 2025cited by 113position: middledoi
Real-World Experience with Teclistamab for Relapsed/Refractory Multiple Myeloma from the US Myeloma Immunotherapy Consortium
Blood Cancer Discovery 2025cited by 14position: middledoi
Bridging intensity is associated with impaired hematopoietic recovery after BCMA CAR-T therapy for multiple myeloma
Blood Advances 2025cited by 10position: middledoi
EASIX-guided risk stratification for complications and outcome after CAR T-cell therapy with ide-cel in relapsed/refractory multiple myeloma
Journal for ImmunoTherapy of Cancer 2024cited by 38position: middledoi
Phase 2 Registrational Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma: Preliminary Results from the IMMagine-1 Trial
Blood 2024cited by 18position: middledoi
High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma
Blood 2023cited by 46position: middledoi
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
Blood 2023cited by 41position: middledoi
Updated phase I study results of PHE885, a T-Charge manufactured BCMA-directed CAR-T cell therapy, for patients (pts) with r/r multiple myeloma (RRMM).
Journal of Clinical Oncology 2023cited by 37position: firstdoi
Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis
Blood Cancer Discovery 2023cited by 31position: middledoi
Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Clinical Cancer Research 2023cited by 27position: middledoi
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of <i>KMT2A</i>-r and <i>NPM1c</i> AML
Blood 2023cited by 26position: middledoi
The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein
iScience 2023cited by 8position: middledoi
Lenalidomide promotes the development of <i>TP53</i>-mutated therapy-related myeloid neoplasms
Blood 2022cited by 137position: firstdoi
Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells
Journal of Clinical Investigation 2022cited by 62position: middledoi
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
Nature Communications 2022cited by 36position: middledoi
Functional dissection of inherited non-coding variation influencing multiple myeloma risk
Nature Communications 2022cited by 30position: middledoi
Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19
Blood 2022cited by 26position: middledoi
Author Correction: Functional dissection of inherited non-coding variation influencing multiple myeloma risk
Nature Communications 2022cited by 1position: middledoi
Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
Nature Communications 2021cited by 404position: middledoi
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
Science Translational Medicine 2021cited by 254position: middledoi
Association of clonal hematopoiesis with chronic obstructive pulmonary disease
Blood 2021cited by 227position: middledoi
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
Nature Reviews Clinical Oncology 2021cited by 135position: middledoi
Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy
Blood Advances 2021cited by 119position: middledoi
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216
Journal of Medicinal Chemistry 2021cited by 55position: middledoi
Modeling and targeting of erythroleukemia by hematopoietic genome editing
Blood 2021cited by 43position: middledoi
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Nature 2020cited by 405position: middledoi
Small-molecule-induced polymerization triggers degradation of BCL6
Nature 2020cited by 267position: middledoi
Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade
JCO Precision Oncology 2020cited by 43position: middledoi
Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis
Blood 2020cited by 33position: middledoi
Identification of germline variants in adults with hemophagocytic lymphohistiocytosis
Blood Advances 2020cited by 19position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Benjamin L. Ebert · Harvard University17 papers (2019–2023)Peter G. Miller · Brigham and Women's Hospital11 papers (2019–2023)Nikhil C. Munshi · Harvard University9 papers (2013–2024)Christopher J. Gibson · Merck & Co., Inc., Rahway, NJ, USA (United States)8 papers (2020–2023)Mikołaj Słabicki · Broad Institute6 papers (2019–2023)Mariateresa Fulciniti · Harvard University6 papers (2014–2023) · 5 papers (2019–2023)Eric S. Fischer · Harvard University5 papers (2020–2023)Katherine A. Donovan · Harvard University5 papers (2020–2023)Kenneth C. Anderson · Baptist Health Louisville5 papers (2013–2023)Mehmet Samur · Harvard University5 papers (2014–2023)Max Jan · Harvard University5 papers (2019–2021)Radosław P. Nowak · University of Bonn4 papers (2020–2023)Yu‐Tzu Tai · Cancer Research Center4 papers (2014–2021)Paul G. Richardson · Harvard University4 papers (2013–2023)Hervé Avet‐Loiseau · Institut universitaire du cancer de Toulouse Oncopole4 papers (2014–2023)Marie McConkey · Dana-Farber Cancer Institute3 papers (2020–2023) · 3 papers (2020–2023)Sarah Nikiforow · Harvard University3 papers (2020–2023)Donna Neuberg · Massachusetts General Hospital3 papers (2021–2023)