Area of research
Radiology, Nuclear Medicine and Imaging · Molecular Biology
Research interest
Research focused on Nuclear medicine and Positron emission tomography, with related work in Neuroinflammation, In vivo, Biodistribution. Notable publications include 'Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18 F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles', '18 F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446', and 'Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates'.
Selective PET imaging of CXCR4 using the Al18F-labeled antagonist LY2510924
Translation of HDAC6 PET Imaging Using [<sup>18</sup>F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates
TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study
Binding of [18F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
<sup>18</sup>F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446
Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers
Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
Comparison of New Tau PET-Tracer Candidates With [ <sup>18</sup> F]T808 and [ <sup>18</sup> F]T807
PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide
PET Radioligands for In Vivo Visualization of Neuroinflammation
Quantification of <sup>18</sup>F-JNJ-42259152, a Novel Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test–Retest Study in Human Brain
Preclinical evaluation of [18F]JNJ42259152 as a PET tracer for PDE10A
Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging
Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging