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Mikael Simons

German Center for Neurodegenerative Diseases · DE
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Area of research
Neurology · Developmental Neuroscience
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Neurogenesis and neuroplasticity mechanisms, Alzheimer's disease research and treatments, and Immune cells in cancer.
h-index
84
citations
35,560
works
233
NIH funding
primary concept
Biology
email

Recent publications

Lipid metabolism and neuroinflammation: What is the link?
The Journal of Experimental Medicine 2025cited by 11position: lastdoi
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding
The EMBO Journal 2025cited by 10position: middledoi
Neuroinflammation in Alzheimer disease
Nature reviews. Immunology 2024cited by 367position: middledoi
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
Immunity 2024cited by 34position: lastdoi
Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease
Journal of Neuroinflammation 2024cited by 26position: middledoi
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Molecular Neurodegeneration 2024cited by 5position: middledoi
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Nature 2023cited by 409position: middledoi
Myelination generates aberrant ultrastructure that is resolved by microglia
The Journal of Cell Biology 2023cited by 81position: lastdoi
Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
Molecular Psychiatry 2023cited by 42position: middledoi
Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects
Nature Communications 2023cited by 39position: middledoi
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
EBioMedicine 2023cited by 30position: middledoi
Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease
Research Square 2023cited by 0position: middledoi
Microglia states and nomenclature: A field at its crossroads
Neuron 2022cited by 1,824position: middledoi
Tau deposition patterns are associated with functional connectivity in primary tauopathies
Nature Communications 2022cited by 104position: middledoi
Associations between sex, body mass index, and the individual microglial response in Alzheimer’s disease
Alzheimer s & Dementia 2021cited by 1position: middledoi
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Science 2020cited by 2,026position: lastdoi
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Molecular Systems Biology 2020cited by 310position: middledoi
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain
Cell Metabolism 2020cited by 185position: lastdoi
A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature
Journal of Neuroscience 2020cited by 157position: middledoi
Nutrient signaling pathways regulate amyloid clearance and synaptic loss in Alzheimer’s disease
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 3position: middledoi
Isolation and Culture of Oligodendrocytes
Methods in molecular biology 2019cited by 22position: lastdoi
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
Cell 2018cited by 666position: middledoi
Disease Modification in Multiple Sclerosis by Flupirtine—Results of a Randomized Placebo Controlled Phase II Trial
Frontiers in Neurology 2018cited by 8position: middledoi
Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone
Stem Cells 2016cited by 30position: middledoi
The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane
Nature Cell Biology 2015cited by 147position: middledoi
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
Cell 2014cited by 448position: lastdoi
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
PLoS Biology 2013cited by 856position: middledoi
A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production
Cell Reports 2013cited by 160position: middledoi
Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension
Experimental Eye Research 2013cited by 20position: middledoi
Toll‐like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia
Glia 2012cited by 102position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Martina Schifferer · Technical University of Munich5 papers (2018–2025) · 3 papers (2013–2020) · 3 papers (2013–2023)Klaus‐Armin Nave · Max Planck Institute of Experimental Medicine3 papers (2013–2020) · 2 papers (2019–2020)Saskia Hutten · Johannes Gutenberg University Mainz2 papers (2018–2025) · 2 papers (2020–2023) · 2 papers (2013–2018) · 2 papers (2016–2023)Eva‐Maria Krämer‐Albers · Johannes Gutenberg University Mainz2 papers (2013–2020)Dorothee Dormann · Johannes Gutenberg University Mainz2 papers (2018–2025)Doron Merkler · Hue University2 papers (2012–2014)Anja Schneider · University of Bonn2 papers (2013–2020)Vini Tiwari · German Center for Neurodegenerative Diseases2 papers (2024–2025)Jan Hegermann · Medizinische Hochschule Hannover1 papers (2023–2023)Henrik Zetterberg · Indian Institute of Science Bangalore1 papers (2020–2020) · 1 papers (2020–2020)Magdalini Polymenidou · University of Zurich1 papers (2025–2025)David A. Lyons · University of Edinburgh1 papers (2014–2014)Dominik Fröhlich · Johannes Gutenberg University Mainz1 papers (2013–2013)
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