Area of research
Cell Biology · Molecular Biology
Research interest
Research interests include Endoplasmic Reticulum Stress and Disease, RNA regulation and disease, Ubiquitin and proteasome pathways, and CRISPR and Genetic Engineering.
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
<scp>The importance of naturally attenuated SARS‐CoV</scp> ‐2 <scp>in the fight against COVID</scp> ‐19
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
An unfolded protein-induced conformational switch activates mammalian IRE1
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells
Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Pharmacological brake-release of mRNA translation enhances cognitive memory