Area of research
Molecular Biology · Organic Chemistry
Research interest
Research interests include Click Chemistry and Applications, Genomics, phytochemicals, and oxidative stress, Zebrafish Biomedical Research Applications, and CRISPR and Genetic Engineering.
Large-scale F0 CRISPR screens in vivo using MIC-Drop
Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish
Z-REX uncovers a bifurcation in function of Keap1 paralogs
MIC-Drop: A platform for large-scale in vivo CRISPR screens
Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles
Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups
Redox Signaling by Reactive Electrophiles and Oxidants
Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo
T-REX on-demand redox targeting in live cells