Area of research
Cancer Research · Computational Theory and Mathematics
Research interest
Research interests include Cancer Genomics and Diagnostics, Computational Drug Discovery Methods, Lung Cancer Treatments and Mutations, and Chronic Myeloid Leukemia Treatments.
Targeting the chromatin modifying enzyme, KDM5C, enhances AKT inhibition response in ER+ breast cancer.
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
Predicting Personalised Therapeutic Combinations in Non-Small Cell Lung Cancer Using In Silico Modelling
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
Abstract 2945: Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
ctDNA monitoring using patient-specific sequencing and integration of variant reads
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia
High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
The evolutionary landscape of colorectal tumorigenesis
The germline genetic component of drug sensitivity in cancer cell lines
Precision oncology for acute myeloid leukemia using a knowledge bank approach
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
A pilot study of individualised monitoring of patients with metastatic melanoma using plasma and urine DNA.
A Landscape of Pharmacogenomic Interactions in Cancer
Mutational signatures of ionizing radiation in second malignancies
BRAFV600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
The evolutionary history of lethal metastatic prostate cancer
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma
Abstract 956: The evolutionary history of lethal metastatic prostate cancer
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes