Area of research
Molecular Biology · Global and Planetary Change
Research interest
Research interests include Biology, Ciona, Ciona intestinalis, Cell biology, Mesoderm, and Computational biology.
A platform for the biomedical application of large language models
Genome-wide expression gradient estimation based on local pseudotime in single cell RNA sequencing
Structure-primed embedding on the transcription factor manifold enables transparent model architectures for gene regulatory network and latent activity inference
GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate
Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
Optimal tuning of weighted kNN- and diffusion-based methods for denoising single cell genomics data
Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity
A single-cell transcriptional roadmap for cardiopharyngeal fate diversification
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates
Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices
A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory
An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time
Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors
CRISPR Knockouts in Ciona Embryos
Purification of Fluorescent Labeled Cells from Dissociated Ciona Embryos
ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets
Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona
Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes
Fused Regression for Multi-source Gene Regulatory Network Inference
Ciona as a Simple Chordate Model for Heart Development and Regeneration
Transcriptional Control of Developmental Cell Behaviors
Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages
A new heart for a new head in vertebrate cardiopharyngeal evolution
Migratory neuronal progenitors arise from the neural plate borders in tunicates
Regulation and evolution of cardiopharyngeal cell identity and behavior: insights from simple chordates
Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration
Tissue-specific genome editing in <i>Ciona</i> embryos by CRISPR/Cas9
Collier/OLF/EBF-Dependent Transcriptional Dynamics Control Pharyngeal Muscle Specification from Primed Cardiopharyngeal Progenitors
Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians
Guidelines for the nomenclature of genetic elements in tunicate genomes