Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research focused on Pharmacology and Precision oncology, with related work in Cytotoxic T cell, Vismodegib, Cyclin-dependent kinase 6. Notable publications include 'Translational value of mouse models in oncology drug development', 'Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors', and 'Discovery and preclinical development of vismodegib'.
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Translational value of mouse models in oncology drug development
Discovery and preclinical development of vismodegib
Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis