Area of research
Aging · Cancer Research
Research interest
Research focused on Longevity and Computational biology, with related work in Genetics, Psychological intervention, Germline. Notable publications include 'Interventions to Slow Aging in Humans: Are We Ready?', 'Differences between germline and somatic mutation rates in humans and mice', and 'Genome Instability and Aging'.
The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity
SenNet recommendations for detecting senescent cells in different tissues
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses
A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory function
Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination
Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of <i> p16 <sup>INK4a</sup> </i>
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation
Genetics of extreme human longevity to guide drug discovery for healthy ageing
ARDD 2020: from aging mechanisms to interventions
Differences between germline and somatic mutation rates in humans and mice
Genomewide meta‐analysis identifies loci associated with <scp>IGF</scp> ‐I and <scp>IGFBP</scp> ‐3 levels with impact on age‐related traits
Interventions to Slow Aging in Humans: Are We Ready?
LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
An epigenomic role of Fe65 in the cellular response to DNA damage
Genome Instability and Aging
Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria