Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiac electrophysiology and arrhythmias, Ion channel regulation and function, Atrial Fibrillation Management and Outcomes, and Neuroscience and Neural Engineering.
Modulation of cardiomyocyte contractility and action potentials with chemogenetic chloride currents.
Human induced pluripotent stem cell-derived atrial cardiomyocytes recapitulate contribution of the slowly activating delayed rectifier currents IKs to repolarization in the human atrium.
Dapagliflozin and atrial fibrillation: elevated dosing to achieve class I antiarrhythmic effects?
<i>PITX2</i> Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation.
Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES.
Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle.
Mind the gap: leak currents and induced pluripotent stem cell-derived cardiomyocytes in translational cardiac electrophysiology.
Comprehensive analyses of the inotropic compound omecamtiv mecarbil in rat and human cardiac preparations.
Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel disease mechanism
Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner
Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation.
Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?
Regulation of basal and norepinephrine-induced cAMP and I<sub>Ca</sub> in hiPSC-cardiomyocytes: Effects of culture conditions and comparison to adult human atrial cardiomyocytes.
No impact of sex and age on beta-adrenoceptor-mediated inotropy in human right atrial trabeculae.
Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease.
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology?
Ca<sup>2+</sup> currents in cardiomyocytes: How to improve interpretation of patch clamp data?
Intermittent Optogenetic Tachypacing of Atrial Engineered Heart Tissue Induces Only Limited Electrical Remodelling.
Regulation of I<sub>Ca,L</sub> and force by PDEs in human-induced pluripotent stem cell-derived cardiomyocytes.
Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I<sub>bk,Ca</sub>).
Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.
Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation.
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.
Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.
DPP10 is a new regulator of Nav1.5 channels in human heart.
Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes.