Area of research
Pharmacology · Emergency Medicine
Research interest
Research interests include Drug-Induced Hepatotoxicity and Protection, Poisoning and overdose treatments, MicroRNA in disease regulation, and Extracellular vesicles in disease.
Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA-122 in hospital clinical laboratories.
Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time.
Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic.
The emerging role of alternatively activated macrophages to treat acute liver injury.
HiSNAP trial-a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: study protocol.
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse.
Antidotes in the management of poisoned patients: What have we gained over the last decade?
A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay.
Scottish and Newcastle Antiemetic Protocol (SNAP) 12-hour acetylcysteine regimen for paracetamol overdose reduces anaphylactoid reactions without compromising hepatic protection in all age groups: a secondary analysis.
Adverse drug reactions, particularly liver disorders, drive interruptions in anti-tuberculosis treatment: A retrospective cohort study.
SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse.
Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA-122 in hospital clinical laboratories
Adverse drug reactions, particularly liver disorders, drive prolonged interruptions in anti-tuberculosis treatment: a retrospective cohort study
A new point of care diagnostic for the sensitive and specific diagnosis of drug-induced liver injury using a surface enhanced Raman scattering lateral flow immunoassay (SERS-LFIA)
No action is without its side effects: Adverse drug reactions and missed doses of antituberculosis therapy, a scoping review.
Circulating microRNA detection using electrochemical biosensor for rapid diagnosis of liver disease in dogs
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
Study protocol: HiSNAP trial – a multi-centre, randomised, open label, blinded end-point, safety and efficacy trial of conventional (300mg/kg) versus higher doses of acetylcysteine (450mg/kg and 600mg/kg) in patients with paracetamol overdose in the United Kingdom
Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis.
Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury
SLAMseq reveals transfer of RNA from liver to kidney in the mouse
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse
Small interfering RNA: Discovery, pharmacology and clinical development-An introductory review.
Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment
An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).
Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment.
No action is without its side effects: Adverse drug reactions and missed doses of antituberculosis therapy, a scoping review
Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver.