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Kevin S. O’Connell

University of Cape Town · ZA
Area of research
Genetics · Psychiatry and Mental health
Research interest
Research focused on Genome-wide association study and Bipolar disorder, with related work in Genetic architecture, Schizophrenia (object-oriented programming), Genetic association. Notable publications include 'Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology', 'Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation', and 'Discovery of shared genomic loci using the conditional false discovery rate approach'.
h-index
citations
4,040
works
32
NIH funding
primary concept
email

Recent publications

Genomics yields biological and phenotypic insights into bipolar disorder
Nature 2025cited by 144position: firstdoi
Mapping the genetic landscape across 14 psychiatric disorders
Nature 2025cited by 43position: middledoi
Fine-mapping genomic loci refines bipolar disorder risk genes
Nature Neuroscience 2025cited by 20position: middledoi
The Psychiatric Genomics Consortium: discoveries and directions
The Lancet Psychiatry 2025cited by 19position: middledoi
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience 2025cited by 13position: middledoi
Recommendations for defining treatment outcomes in major psychiatric disorders using real-world data
The Lancet Psychiatry 2025cited by 13position: middledoi
New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways
Biological Psychiatry 2025cited by 8position: firstdoi
Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets
Nature Genetics 2024cited by 29position: middledoi
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Brain 2023cited by 51position: middledoi
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
The Lancet Psychiatry 2023cited by 44position: middledoi
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Genome Medicine 2023cited by 41position: middledoi
Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
Nature Human Behaviour 2023cited by 36position: middledoi
Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
Schizophrenia Bulletin 2023cited by 33position: middledoi
Bidirectional genetic overlap between autism spectrum disorder and cognitive traits
Translational Psychiatry 2023cited by 23position: middledoi
Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts
Biological Psychiatry 2023cited by 19position: middledoi
Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology
Biological Psychiatry 2022cited by 62position: middledoi
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood
Molecular Psychiatry 2022cited by 50position: middledoi
Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation
Biological Psychiatry 2022cited by 49position: middledoi
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Nature Genetics 2021cited by 1,563position: middledoi
Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness
JAMA Psychiatry 2021cited by 98position: middledoi
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Brain 2021cited by 65position: middledoi
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
Brain Behavior and Immunity 2021cited by 65position: middledoi
Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes
Biological Psychiatry 2021cited by 61position: firstdoi
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
Translational Psychiatry 2021cited by 54position: middledoi
Genetic loci shared between major depression and intelligence with mixed directions of effect
Nature Human Behaviour 2021cited by 49position: middledoi
Genome-wide association study identifies 48 common genetic variants associated with handedness
Nature Human Behaviour 2020cited by 154position: middledoi
Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders
JAMA Psychiatry 2020cited by 144position: middledoi
Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
Biological Psychiatry 2020cited by 102position: middledoi
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Nature Communications 2019cited by 435position: middledoi
Discovery of shared genomic loci using the conditional false discovery rate approach
Human Genetics 2019cited by 254position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Oleksandr Frei · University of Oslo21 papers (2019–2025)Anders M. Dale · Oslo University Hospital21 papers (2019–2025)Ole A. Andreassen · University of Zurich21 papers (2019–2025)Alexey Shadrin · University of Oslo21 papers (2019–2025)Olav B. Smeland · Oslo University Hospital20 papers (2019–2025)Srdjan Djurovic · Oslo University Hospital20 papers (2019–2025)Shahram Bahrami · University of Oslo19 papers (2019–2025)Guy Hindley · University of Oslo14 papers (2021–2025)Nils Eiel Steen · University of Oslo12 papers (2019–2025)Weiqiu Cheng · University of Oslo11 papers (2021–2024)Nadine Parker · University of Oslo9 papers (2022–2025)Chun Chieh Fan · University of California San Diego8 papers (2019–2023)Aihua Lin · Guangzhou University of Chinese Medicine8 papers (2021–2023)Francesco Bettella · University of Oslo7 papers (2019–2022)Naz Karadag · University of Oslo6 papers (2021–2023)Børge Holen · University of Oslo6 papers (2022–2023)Zillur Rahman · University of Oslo5 papers (2023–2023)Florian Krull · University of Oslo5 papers (2019–2021)Linn Rødevand · University of Oslo5 papers (2021–2025)Yunpeng Wang · Oslo University Hospital4 papers (2019–2022)