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Jacques Deguine

Massachusetts Institute of Technology · US
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Area of research
Immunology
Research interest
Research focused on Immunology and Inflammation, with related work in Transcriptome, Immune system, Eosinophilic esophagitis. Notable publications include 'The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon', 'A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma', and 'B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV'.
h-index
citations
604
works
9
NIH funding
primary concept
email

Recent publications

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis
Nature Communications 2026cited by 1position: middledoi
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Science 2025cited by 20position: middledoi
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
The Journal of Experimental Medicine 2025cited by 1position: middledoi
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
Nature Communications 2024cited by 55position: middledoi
B cell tolerance and autoimmunity: Lessons from repertoires
The Journal of Experimental Medicine 2024cited by 11position: firstdoi
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon
Immunity 2023cited by 253position: middledoi
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma
Science Immunology 2023cited by 133position: middledoi
Remodeling of colon plasma cell repertoire within ulcerative colitis patients
The Journal of Experimental Medicine 2023cited by 31position: middledoi
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Cell 2021cited by 99position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ramnik J. Xavier · Broad Institute7 papers (2023–2025)Daniel B. Graham · Broad Institute4 papers (2023–2025)Ariel Lefkovith · Massachusetts Institute of Technology3 papers (2023–2024)Grace T. Carter · McGill University Health Centre2 papers (2023–2024)Aviv Regev · Moscow Institute of Thermal Technology2 papers (2023–2024)Lingjia Kong · Massachusetts Institute of Technology2 papers (2023–2025)Elizabeth A. Creasey · Tufts University2 papers (2023–2025)Orr Ashenberg · Broad Institute2 papers (2023–2024)Ashwin N. Ananthakrishnan · Harvard University2 papers (2023–2023)Toni Delorey · Broad Institute2 papers (2023–2024) · 1 papers (2023–2023)Habib Zaghouani · University of Missouri1 papers (2025–2025)Alex K. Shalek · Broad Institute1 papers (2025–2025) · 1 papers (2025–2025)Kyle Staller · Harvard University1 papers (2024–2024) · 1 papers (2023–2023)Basak Eraslan · Massachusetts Institute of Technology1 papers (2023–2023)Chenhao Li · Jilin University1 papers (2025–2025)Helena Lau · Harvard University1 papers (2023–2023)Hai Ning Shi · University of Colorado Denver1 papers (2025–2025)
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