Mark L. Dell’Acqua

The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment.

Synapse-to-Nucleus ERK→CREB Transcriptional Signaling Requires Dendrite-to-Soma Ca<sup>2+</sup> Propagation Mediated by L-Type Voltage-Gated Ca<sup>2+</sup> Channels.

Amyloid-β-induced dendritic spine elimination requires Ca<sup>2+</sup>-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and the NFAT target gene Mdm2.

AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.

Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling.

miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.

Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction

Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses.

The Ca_V1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca²⁺ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome.

Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.

β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca²⁺-permeable AMPA receptors.

Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.

AKAP79/150 coordinates leptin-induced PKA signaling to regulate K_ATP channel trafficking in pancreatic β-cells.

Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits.

Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease

Phosphorylation-Dependent Regulation of Ca²⁺-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity.

Local miRNA-Dependent Translational Control of GABA_AR Synthesis during Inhibitory Long-Term Potentiation.

AKAP79/150 coordinates leptin-induced PKA activation to regulate K _ATP channel trafficking in pancreatic β-cells

Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.

Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca²⁺ Channel Ca²⁺ Spike Propagation to the Soma.

AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca²⁺ channels.

Synaptic crosstalk conferred by a zone of differentially regulated Ca²⁺ signaling in the dendritic shaft adjoining a potentiated spine.

Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) <i>γ</i> Isoform are Regulated through Binding to the Phosphatase Calcineurin.

Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca ²⁺ -Permeable AMPA Receptors

Selective Down-regulation of KV2.1 Function Contributes to Enhanced Arterial Tone during Diabetes

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors

AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling