Area of research
Molecular Biology · Genetics
Research interest
Research interests include Peroxisome Proliferator-Activated Receptors, Estrogen and related hormone effects, Drug Transport and Resistance Mechanisms, and Cholesterol and Lipid Metabolism.
Protein–ligand data at scale to support machine learning
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma
A data science roadmap for open science organizations engaged in early-stage drug discovery
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Target 2035 – update on the quest for a probe for every protein
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
Progress towards a public chemogenomic set for protein kinases and a call for contributions
The promise and peril of chemical probes
Comprehensive characterization of the Published Kinase Inhibitor Set
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B