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Ann M. Graybiel

McGovern Institute for Brain Research · US
Area of research
Cellular and Molecular Neuroscience · Cognitive Neuroscience
Research interest
Research interests include Neuroscience and Neuropharmacology Research, Neural dynamics and brain function, Neurological disorders and treatments, and Neurotransmitter Receptor Influence on Behavior.
h-index
126
citations
58,394
works
475
NIH funding
primary concept
email

Recent publications

Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys
npj Complexity 2026cited by 0position: middledoi
Surprises From the Basal Ganglia: Stop and Go Have New Meaning
Movement Disorders 2025cited by 8position: firstdoi
Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits
Current Biology 2024cited by 41position: lastdoi
Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network
Nature Communications 2024cited by 23position: middledoi
Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 12position: lastdoi
Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease
Nature Communications 2023cited by 68position: lastdoi
Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action
Annual Review of Neuroscience 2023cited by 58position: firstdoi
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
Biosensors and Bioelectronics 2023cited by 24position: middledoi
Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task
Nature Communications 2022cited by 37position: lastdoi
The Role of the Dorsal–Lateral Prefrontal Cortex in Reward Sensitivity During Approach–Avoidance Conflict
Cerebral Cortex 2021cited by 66position: middledoi
CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors
Neurobiology of Disease 2021cited by 19position: lastdoi
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model
Cell 2020cited by 62position: lastdoi
Dopamine and beta-band oscillations differentially link to striatal value and motor control
Science Advances 2020cited by 51position: lastdoi
Neuronal-specific microexon splicing of <i>TAF1</i> mRNA is directly regulated by SRRM4/nSR100
RNA Biology 2019cited by 27position: middledoi
Miniaturized neural system for chronic, local intracerebral drug delivery
Science Translational Medicine 2018cited by 99position: middledoi
Inversely Active Striatal Projection Neurons and Interneurons Selectively Delimit Useful Behavioral Sequences
Current Biology 2018cited by 94position: lastdoi
The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra
PLoS ONE 2018cited by 79position: middledoi
Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model
Communications Biology 2018cited by 79position: lastdoi
Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization
Neuron 2018cited by 71position: middledoi
Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
Scientific Reports 2017cited by 180position: middledoi
Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making
Cell 2017cited by 175position: lastdoi
Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin?
Journal of Neurology Neurosurgery & Psychiatry 2017cited by 135position: lastdoi
Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses
eLife 2017cited by 110position: lastdoi
Long-term dopamine neurochemical monitoring in primates
Proceedings of the National Academy of Sciences 2017cited by 105position: lastdoi
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events
Journal of Neural Transmission 2017cited by 69position: middledoi
Subcellular probes for neurochemical recording from multiple brain sites
Lab on a Chip 2017cited by 65position: middledoi
Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons
Proceedings of the National Academy of Sciences 2016cited by 179position: lastdoi
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
Nature Neuroscience 2016cited by 127position: middledoi
Amygdala-ventral striatum circuit activation decreases long-term fear
eLife 2016cited by 88position: middledoi
Habit formation coincides with shifts in reinforcement representations in the sensorimotor striatum
Journal of Neurophysiology 2016cited by 68position: lastdoi

Grants

Development of the Striatum
NSF8720475$310,6861988–1991PIRePORTER
Development of the Striatum
NSF8319547$343,0001984–1988PIRePORTER
Compartmental Nature of the Connections and Histochemistry Of the Superior Colliculus and Cerebellar Cortex
NSF8112125$293,7851981–1985PIRePORTER
An Experimental Anatomical Study of the Oculomotor System
NSF7810549$245,8911978–1982PIRePORTER
Anatomical Study of the Oculomotor System
NSF7518758$184,6571975–1979PIRePORTER
Experimental Anatomical Study of the Oculomotor System
NSF7301547$43,7001900–1900PIRePORTER

Frequent collaborators

Ken‐ichi Amemori · Massachusetts Institute of Technology9 papers (2015–2024)Tomoko Yoshida · Massachusetts Institute of Technology8 papers (2017–2024)Michael J. Cima · Massachusetts Institute of Technology7 papers (2017–2023)Jill R. Crittenden · Massachusetts Institute of Technology7 papers (2016–2024)Helen N. Schwerdt · Massachusetts Institute of Technology6 papers (2017–2023)Róbert Langer · Laboratoire d’immunologie intégrative du cancer6 papers (2017–2020)Satoko Amemori · Massachusetts Institute of Technology5 papers (2017–2024)A. Matsushima · Massachusetts Institute of Technology4 papers (2023–2024)Leif Gibb · Massachusetts Institute of Technology4 papers (2015–2020)Sébastien Delcasso · Massachusetts Institute of Technology3 papers (2017–2020)Alexander Friedman · Massachusetts Institute of Technology3 papers (2015–2020)Daniel J. Gibson · McGovern Institute for Brain Research3 papers (2015–2020)Daigo Homma · Massachusetts Institute of Technology3 papers (2015–2017)Bernard Bloem · Massachusetts Institute of Technology3 papers (2017–2022)Mark W. Howe · Boston University3 papers (2012–2014)Emily Hueske · Massachusetts Institute of Technology3 papers (2020–2024)Hideki Shimazu · Massachusetts Institute of Technology3 papers (2017–2018)Dan Hu · Massachusetts Institute of Technology3 papers (2012–2020)Kyle S. Smith · Massachusetts Institute of Technology3 papers (2012–2016)Theresa M. Desrochers · Allen Institute for Brain Science2 papers (2015–2026)