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Thomas Fleming

Diabetesinstitut Heidelberg · DE
Area of research
Clinical Biochemistry · Physiology
Research interest
Research interests include Advanced Glycation End Products research, Pain Mechanisms and Treatments, Biochemical effects in animals, and Metabolism, Diabetes, and Cancer.
h-index
41
citations
17,039
works
180
NIH funding
primary concept
Medicine
email

Recent publications

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.
2026cited by 0position: contributordoi
Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish
Cell Reports 2025cited by 6position: middledoi
Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets.
2025cited by 2position: contributordoi
Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes.
2025cited by 0position: contributordoi
Menaquinone-7 Supplementation Increases Multiple Advanced Glycation End-Products and Oxidation Markers in Zucker Diabetic Fatty Rats.
2025cited by 0position: contributordoi
Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain.
2024cited by 25position: contributordoi
The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes.
2024cited by 6position: contributordoi
Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets
Diabetes 2024cited by 5position: lastdoi
Glyoxal in hyperglycaemic ischemic stroke – a cohort study
Cardiovascular Diabetology 2023cited by 10position: middledoi
Ketone body oxidation increases cardiac endothelial cell proliferation
EMBO Molecular Medicine 2022cited by 61position: middledoi
Diabetic neuropathy is a generalized phenomenon with impact on hand functional performance and quality of life
European Journal of Neurology 2022cited by 16position: middledoi
Quantification of All-Trans Retinoic Acid by Liquid Chromatography–Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes
Metabolites 2021cited by 15position: middledoi
Methylglyoxal Induces Endothelial Dysfunction via Stunning-like Phenotype
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 1position: firstdoi
Intermittent fasting has short-term effects on albuminuria, AGE formation and acylcarnitines in patients with type 2 diabetes mellitus
Diabetologie und Stoffwechsel 2021cited by 0position: middledoi
Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1
Cell Reports 2020cited by 18position: lastdoi
Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength
Scientific Reports 2020cited by 17position: lastdoi
CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy
Diabetes 2020cited by 16position: middledoi
Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 0position: lastdoi
O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure
Circulation 2019cited by 120position: middledoi
Statine und Hsp70: Neuer Therapieansatz in der Prävention diabetischer Spätschäden?
Diabetologie und Stoffwechsel 2019cited by 0position: middledoi
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes
Cell Metabolism 2018cited by 170position: middledoi
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Molecular Metabolism 2018cited by 69position: middledoi
Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions
VASA 2018cited by 15position: middledoi
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism – What We Know in Mammals and What We Can Learn From Yeast
Experimental and Clinical Endocrinology & Diabetes 2018cited by 12position: middledoi
Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
Nucleic Acids Research 2017cited by 83position: middledoi
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux
Redox Biology 2017cited by 43position: middledoi
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice
Redox Biology 2017cited by 42position: middledoi
ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy
Journal of Diabetes and its Complications 2017cited by 23position: middledoi
Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma
BMC Cancer 2017cited by 19position: middledoi
A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage
Cell Reports 2017cited by 10position: middledoi

Grants

Collaborative Research: High Precision U-Pb Geochronology of the Jurassic Ferrar Large Igneous Province, Antarctica
NSF0739732$60,3922008–2011PIRePORTER
Collaborative Research: Emplacement of the Ferrar Mafic Igneous Province: A Pilot Study of Intrusive Architecture and Flow Directions in Southern Victoria Land
NSF0126106$54,0902002–2005PIRePORTER

Frequent collaborators

Peter P. Nawroth · Endokrinologikum26 papers (2012–2024)Stephan Herzig · Heidelberg University10 papers (2014–2024) · 6 papers (2024–2026)Jakob Morgenstern · University Hospital Heidelberg6 papers (2018–2021)Aurelio A. Teleman · German Cancer Research Center6 papers (2016–2021)Stefan Kopf · University Hospital Schleswig-Holstein6 papers (2014–2022)Johanna Zemva · University Hospital Heidelberg5 papers (2017–2020)Alba Sulaj · Heidelberg University5 papers (2013–2022)Johannes Backs · Helmholtz Association of German Research Centres5 papers (2019–2022)Hans‐Peter Hammes · Heidelberg University4 papers (2014–2020)Hermann-J. Gröne · German Cancer Research Center4 papers (2015–2020)Andreas Fischer · Universitätsmedizin Göttingen3 papers (2021–2022)Alireza Saadatmand · University Hospital Heidelberg3 papers (2020–2020)Maik Brune · University Hospital Heidelberg3 papers (2015–2021)Ζoltan Κender · University Hospital Heidelberg3 papers (2014–2024)Alexandra Moraru · Bucharest University of Economic Studies3 papers (2018–2020)Dittmar Böckler · Technical University of Munich3 papers (2015–2024)Martin Bendszus · University Hospital and Clinics3 papers (2020–2024)H. J. Gröne · German Cancer Research Center3 papers (2013–2019)Matthias Dewenter · University Hospital Heidelberg3 papers (2019–2022)