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Wayne G. Shreffler

Massachusetts Institute of Technology · US
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Area of research
Immunology and Allergy · Surgery
Research interest
Research focused on Oral immunotherapy and Immunology, with related work in Allergy, Peanut allergy, Placebo. Notable publications include 'Oral Immunotherapy for Treatment of Egg Allergy in Children', 'The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease', and 'Omalizumab for the Treatment of Multiple Food Allergies'.
h-index
citations
3,614
works
38
NIH funding
primary concept
email

Recent publications

Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death
Cellular and Molecular Gastroenterology and Hepatology 2025cited by 9position: middledoi
Treatment of Multi-Food Allergy with Omalizumab Compared to Omalizumab-Facilitated Multi-Allergen OIT
Journal of Allergy and Clinical Immunology 2025cited by 6position: middledoi
Exploratory analyses of predictors and correlates of response to omalizumab therapy in patients with multiple food allergies
Journal of Allergy and Clinical Immunology 2025cited by 6position: middledoi
Omalizumab for the Treatment of Multiple Food Allergies
New England Journal of Medicine 2024cited by 289position: middledoi
Dupilumab as an Adjunct to Oral Immunotherapy in Pediatric Patients With Peanut Allergy
Allergy 2024cited by 32position: middledoi
The use and implementation of omalizumab as food allergy treatment: Consensus-based guidance and Work Group Report of the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology
Journal of Allergy and Clinical Immunology 2024cited by 20position: middledoi
Varying Doses of Epicutaneous Immunotherapy With Viaskin Milk vs Placebo in Children With Cow’s Milk Allergy
JAMA Pediatrics 2024cited by 15position: middledoi
Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 2position: middledoi
Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy
Journal of Clinical Investigation 2023cited by 48position: middledoi
Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years’ Time?
The Journal of Allergy and Clinical Immunology In Practice 2023cited by 30position: middledoi
The SunBEAm birth cohort: Protocol design
Journal of Allergy and Clinical Immunology Global 2023cited by 9position: middledoi
Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy
Journal of Allergy and Clinical Immunology 2022cited by 87position: middledoi
Protocol design and synopsis: Omalizumab as Monotherapy and as Adjunct Therapy to Multiallergen OIT in Children and Adults with Food Allergy (OUtMATCH)
Journal of Allergy and Clinical Immunology Global 2022cited by 55position: middledoi
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis
Microbiome 2022cited by 47position: middledoi
Revealing the heterogeneity of CD4+ T cells through single-cell transcriptomics
Journal of Allergy and Clinical Immunology 2022cited by 31position: middledoi
Clonally expanded, GPR15-expressing pathogenic effector T <sub>H</sub> 2 cells are associated with eosinophilic esophagitis
Science Immunology 2021cited by 110position: middledoi
Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells
Journal of Clinical Investigation 2021cited by 101position: middledoi
Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results
The Journal of Allergy and Clinical Immunology In Practice 2021cited by 61position: middledoi
Safety of peanut (Arachis hypogaea) allergen powder-dnfp in children and teenagers with peanut allergy: Pooled summary of phase 3 and extension trials
Journal of Allergy and Clinical Immunology 2021cited by 24position: middledoi
Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells
medRxiv 2021cited by 5position: middledoi
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity
Nature 2020cited by 165position: middledoi
Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results
Journal of Allergy and Clinical Immunology 2020cited by 100position: middledoi
Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study
The Journal of Allergy and Clinical Immunology In Practice 2020cited by 89position: middledoi
Consensus report from the Food Allergy Research &amp; Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit
Journal of Allergy and Clinical Immunology 2020cited by 64position: middledoi
Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy
JAMA 2019cited by 271position: lastdoi
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Nature Immunology 2019cited by 135position: middledoi
Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy
Journal of Allergy and Clinical Immunology 2019cited by 93position: lastdoi
Expansion of the CD4+ effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity
Journal of Allergy and Clinical Immunology 2019cited by 60position: lastdoi
Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens
Journal of Allergy and Clinical Immunology 2019cited by 54position: middledoi
Current and Future Treatment of Peanut Allergy
The Journal of Allergy and Clinical Immunology In Practice 2019cited by 35position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

J. Christopher Love · Massachusetts Institute of Technology8 papers (2015–2023)Bert Ruiter · Massachusetts Institute of Technology7 papers (2015–2021)Duncan M. Morgan · Massachusetts Institute of Technology7 papers (2019–2025)Sarita U. Patil · Massachusetts Institute of Technology6 papers (2015–2023)Neal P. Smith · Broad Institute5 papers (2019–2021)Ang A. Tu · Massachusetts Institute of Technology5 papers (2019–2021)Brian P. Vickery · Emory University5 papers (2012–2024)Brinda Monian · Allen Institute5 papers (2019–2021)Stacie M. Jones · University of Arkansas at Fayetteville4 papers (2012–2024)Qian Yuan · Jiangsu University4 papers (2016–2022)Robert A. Wood · Johns Hopkins University4 papers (2012–2024)Hugh A. Sampson · Mount Sinai Hospital4 papers (2012–2024)David M. Fleischer · Children's Hospital Colorado4 papers (2012–2024)Scott H. Sicherer · Mount Sinai Hospital4 papers (2012–2024)Yamini V. Virkud · Massachusetts Institute of Technology4 papers (2019–2024)Alexandra F. Santos · St Thomas' Hospital3 papers (2015–2023)R. Sharon Chinthrajah · Allergy, Asthma and Clinical Research Center3 papers (2020–2024)J. Andrew Bird · Southwestern Medical Center3 papers (2017–2024)Todd M. Gierahn · Massachusetts Institute of Technology3 papers (2019–2021)Edwin Kim · University of California System3 papers (2017–2024)
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