Ed Reznik

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer

The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes

Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer

A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation

A Phase 2 Trial of Talazoparib and Avelumab in Genomically Defined Metastatic Kidney Cancer

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Phase II Trial of Cabozantinib Plus Nivolumab in Patients With Non–Clear-Cell Renal Cell Carcinoma and Genomic Correlates

Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

Phase and context shape the function of composite oncogenic mutations

Double <i>PIK3CA</i> mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

The Association Between Small Primary Tumor Size and Prognosis in Metastatic Renal Cell Carcinoma: Insights from Two Independent Cohorts of Patients Who Underwent Cytoreductive Nephrectomy

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

The long tail of oncogenic drivers in prostate cancer

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas