Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, PI3K/AKT/mTOR signaling in cancer, Biochemical and Molecular Research, and RNA modifications and cancer.
SLC7A5 is required for cancer cell growth under arginine-limited conditions
Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer
HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-κB pathway
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier
Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma
Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer