Area of research
Molecular Biology · Hematology
Research interest
Research interests include Epigenetics and DNA Methylation, RNA modifications and cancer, Protein Degradation and Inhibitors, and Acute Myeloid Leukemia Research.
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia
Electron transport chain inhibition increases cellular dependence on purine transport and salvage
A glutamine metabolic switch supports erythropoiesis
Niacin supplementation in a child with novel MTTN variant m.5670A>G causing early onset mitochondrial myopathy and NAD+ deficiency
L-2-hydroxyglutaric aciduria – review of literature and case series
Partial N‐acetyl glutamate synthase deficiency presenting as postpartum hyperammonemia: Diagnosis and subsequent pregnancy management
Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan
Compartmentalized metabolism supports midgestation mammalian development
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy
Metabolic impact of pathogenic variants in the mitochondrial <scp>glutamyl‐tRNA</scp> synthetase <scp>EARS2</scp>
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
Vitamin B6-dependent epilepsy due to pyridoxal phosphate-binding protein (PLPBP) defect – First case report from Pakistan and review of literature
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Gain‐of‐function variants in the <i>ODC1</i> gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities
In Situ Capture of Chromatin Interactions by Biotinylated dCas9
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Vitamin D status in chronic dialysis patients with depression: a prospective study