Area of research
Molecular Biology · Computational Theory and Mathematics
Research interest
Research interests include Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Computational Drug Discovery Methods, and Chemical Synthesis and Analysis.
Targeting Apicomplexan Parasites: Structural and Functional Characterization of <i>Cryptosporidium</i> Thioredoxin Reductase as a Novel Drug Target
The “Doorstop Pocket” In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery
Carriers of Heterozygous Loss-of-Function ACE Mutations Are at Risk for Alzheimer’s Disease
Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments
Epitope mapping of novel monoclonal antibodies to human angiotensin I‐converting enzyme
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis
Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels
Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis
Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions
Ectopic suicide inhibition of thioredoxin glutathione reductase
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors
Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity
Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors
Gartanin, an isoprenylated xanthone from the mangosteen fruit (<i>Garcinia mangostana</i>), is an androgen receptor degradation enhancer
Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway<i>in vitro</i>and<i>in vivo</i>
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease
Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors
A Chimeric SERM–Histone Deacetylase Inhibitor Approach to Breast Cancer Therapy
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose