Area of research
Cell Biology · Molecular Biology
Research interest
Research focused on Integrated stress response and Unfolded protein response, with related work in ATF4, Cognitive flexibility, Artemisinin. Notable publications include 'Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility', 'Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency', and 'Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4'.
Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility