Area of research
Molecular Biology · Physical and Theoretical Chemistry · test6
Research interest
Research interests include Protein Degradation and Inhibitors, RNA Interference and Gene Delivery, Chemical Reactions and Mechanisms, and Lung Cancer Treatments and Mutations.
Ultrahigh-Throughput Liquid Chromatography with Tandem Mass Spectrometry Method for Targeted Protein Degradation Compound Screening Using the Orbitrap Astral Mass Spectrometer.
Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue Discovery
Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders
RSPO2-Based Peptibodies Conjugated with Pyrrolobenzodiazepine Dimer or Camptothecin Analogs Demonstrate Potent Antitumor Activity by Targeting the Three Receptors LGR4/5/6 in Colorectal Cancer and Neuroblastoma.
Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders
Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy
Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders
Responder discordance between migraine frequency and patient-reported outcomes after CGRP-pathway monoclonal antibody treatment: a secondary analysis of public patient-level data.
Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in <scp>DN</scp>
A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities.
TRAF2 and RIPK1 redundantly mediate classical NFκB signaling by TNFR1 and CD95-type death receptors.
AlphaFold3 in Drug Discovery: A Comprehensive Assessment of Capabilities, Limitations, and Applications
Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue Discovery
Transcriptional remodeling shapes therapeutic vulnerability to necroptosis in acute lymphoblastic leukemia.
The impact of microplastics on the adsorption of 2,4,6-tribromophenol in soils: Competitive adsorption
COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale
One Tracer, Dual Platforms: Unlocking Versatility of Fluorescent Probes in TR-FRET and NanoBRET Target Engagement Assays.
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
Re: Concerns Regarding the Validation of ZYS-1 as a <i>Bona Fide</i> ADAR1 Inhibitor
Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties.
Metabolism, Pharmacokinetics, and Tissue Distribution of a Selective FK506-Binding Protein 12 F36V Mutant Degrader in Mice.
Statistical Process Monitoring of Cryogenic Air Separation Unit Startups*
Design, Optimization and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties
COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale
Ultra-High-Throughput LC-MS Method for Targeted Protein Degradation Compound Screening Using the Orbitrap Astral Mass Spectrometer
COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale.
One Tracer, Dual Platforms: Unlocking Versatility of Fluorescent Probes in TR-FRET and NanoBRET Target Engagement Assays
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6 in colorectal cancer and neuroblastoma
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer.
eMB: Collaborative Research: Fluid Dynamics and Infectious Diseases: An Integrated Modeling Framework
EAGER: A Novel Multi-Tray Dry Biofilm Reactor for Methane Capture from Air
Deterministic Models for Waterborne Infections
Collaborative Research: Consequences of Environmental Stochasticity for the Spatial Dynamics of Savanna-Forest Transitions
RUI: Computational Methods for Measuring Topological Entanglement in Polymers
Nonequilibrium Dynamics and Thermodynamics of the Cell Cycle
Establishing a Potential and Flux Landscape Theory for Stem Cell Fate Decision Making of Differentiation and Reprograming
I-Math: An Interdisciplinary Math Training Platform
EAGER:Cybermanufacturing:Collaborative Research: A novel process data analytics framework for IoT-enabled cybermanufacturing
QuBBD: Collaborative Research: Precision medicine and the management of infectious diseases
An Integrated Systems Engineering Approach to the Modeling of Cellular Dynamics and Bioreactors
Collaborative Research: New Formulation and Algorithms for Fluid-Structure Interaction, with Application to Tumor Growth
EAGER: A System Identification Based Metabolic Flux Analysis and its Application to Production of Advanced Biofuels
CAREER: Power Electronics and High Voltage Intensive Solutions for Very Large Scale Megawatt Photovoltaic Systems
Exploring Ligand Binding Energy Landscape and Quantifying Specificity of Biomolecular Recognition
Developing a Landscape Theory for Biological Networks: Principle Concepts and Physical Perspectives
Collaborative Research: GOALI: A New Advanced Process Control Framework for Next-Generation High-Mix Semiconductor Manufacturing
Production of Biocrude from Biomass using Supercritical Water
CAREER: Understanding Biomolecular Recognition Involving Large Conformational Changes