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Michael Polydefkis

Mayo Clinic in Arizona · US
Area of research
Molecular Biology · Physiology
Research interest
Research interests include Amyloidosis: Diagnosis, Treatment, Outcomes, Pain Mechanisms and Treatments, Parathyroid Disorders and Treatments, and Skin and Cellular Biology Research.
h-index
52
citations
13,598
works
229
NIH funding
primary concept
Medicine
email

Recent publications

Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy
JAMA Neurology 2025cited by 25position: middledoi
Diagnosis and treatment of hereditary transthyretin amyloidosis with polyneuropathy in the <scp>United States</scp>: <scp>Recommendations</scp> from a panel of experts
Muscle & Nerve 2024cited by 27position: lastdoi
Treatment response and neurofilament light chain levels with long-term patisiran in hereditary transthyretin-mediated amyloidosis with polyneuropathy: 24-month results of an open-label extension study.
2024cited by 17position: contributordoi
Joint Hypermobility, Autonomic Dysfunction, Gastrointestinal Dysfunction, and Autoimmune Markers: Clinical Associations and Response to Intravenous Immunoglobulin Therapy.
2024cited by 7position: contributordoi
A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata.
2024cited by 4position: contributordoi
Symptoms of Hereditary Transthyretin Amyloidosis: The Patient and Physician Perspective.
2024cited by 0position: contributordoi
Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial.
2023cited by 263position: contributordoi
Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy
JAMA 2023cited by 195position: middledoi
Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay
Amyloid 2023cited by 14position: middledoi
Phenotypes Associated With the Val122Ile, Leu58His, and Late-Onset Val30Met Variants in Patients With Hereditary Transthyretin Amyloidosis.
2023cited by 12position: contributordoi
Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial
Amyloid 2022cited by 369position: middledoi
Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS): 14-year update
Orphanet Journal of Rare Diseases 2022cited by 88position: middledoi
Sex Differences in Wild-Type Transthyretin Amyloidosis: An Analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS)
Cardiology and Therapy 2022cited by 45position: middledoi
Long-term efficacy and safety of inotersen for hereditary transthyretin amyloidosis: NEURO-TTR open-label extension 3-year update
Journal of Neurology 2022cited by 34position: middledoi
Sex-Related Risk of Cardiac Involvement in Hereditary Transthyretin Amyloidosis
JACC Heart Failure 2021cited by 73position: middledoi
Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey
JACC CardioOncology 2021cited by 60position: middledoi
Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression
Orphanet Journal of Rare Diseases 2021cited by 51position: middledoi
Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations
PAIN Reports 2021cited by 33position: middledoi
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
The Lancet Neurology 2020cited by 156position: middledoi
Early data on long‐term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2‐year update from the open‐label extension of the NEURO‐TTR trial
European Journal of Neurology 2020cited by 71position: middledoi
Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria.
2020cited by 59position: contributordoi
A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis
Orphanet Journal of Rare Diseases 2020cited by 51position: middledoi
Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7
Journal of the Neurological Sciences 2019cited by 112position: middledoi
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
New England Journal of Medicine 2018cited by 2,881position: middledoi
Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
New England Journal of Medicine 2018cited by 1,407position: middledoi
Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial
Amyloid 2018cited by 26position: middledoi
The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations
Journal of Pain 2017cited by 153position: middledoi
Assessing mNIS+7<sub>Ionis</sub> and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial
Muscle & Nerve 2017cited by 55position: middledoi
Na<sub>V</sub>channel variants in patients with painful and nonpainful peripheral neuropathy
Neurology Genetics 2017cited by 38position: middledoi
Peripheral neuropathic changes in pachyonychia congenita
Pain 2016cited by 22position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

· 7 papers (2020–2024)John L. Berk · Boston University6 papers (2018–2023)David Adams · San Francisco Department of Public Health5 papers (2020–2024)Teresa Coelho · ERN GUARD-Heart5 papers (2018–2022)P. James B. Dyck · Mayo Clinic4 papers (2018–2022)Morie A. Gertz · Mayo Clinic3 papers (2018–2022)Márcia Waddington‐Cruz · Universidade Federal do Rio de Janeiro3 papers (2018–2020)Violaine Planté‐Bordeneuve · Inserm3 papers (2020–2022)Thomas H. Brannagan · Columbia University Irving Medical Center3 papers (2020–2024)Isabel Conceição · Administração Regional de Saúde de Lisboa e Vale do Tejo3 papers (2020–2022)Laura Obici · University of Pavia3 papers (2019–2022)Alejandra González‐Duarte · New York University3 papers (2019–2024)Giampaolo Merlini · Amyloidosis Foundation2 papers (2020–2022)Merrill D. Benson · The University of Texas Southwestern Medical Center2 papers (2018–2022)Shiangtung W. Jung · Ionis Pharmaceuticals (United States)2 papers (2018–2020) · 2 papers (2023–2024)Annabel K. Wang · University of California, Irvine2 papers (2018–2022)Fábio Barroso · Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia2 papers (2018–2020)Josep Maria Campistol Plana · Universitat de Barcelona1 papers (2022–2022)Josep Gámez · Hospital Clínic de Barcelona1 papers (2022–2022)