Area of research
Cancer Research · Computational Theory and Mathematics
Research interest
Research focused on Lactate dehydrogenase and CRISPR, with related work in Lactate dehydrogenase A, In vivo, Druggability. Notable publications include 'Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9', 'Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)', and 'Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy'.
Pan-cancer proteogenomics expands the landscape of therapeutic targets
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9