Area of research
Biomedical Engineering · Molecular Biology
Research interest
Research topics from publications: Dual H2O2‐Amplified Nanofactory for Simultaneous Self‐Enhanced NIR‐II Fluorescence Activation Imaging and Synergistic Tumor Therapy; A Novel Activatable Nanoradiosensitizer for Second Near‐Infrared Fluorescence Imaging‐Guided Safe‐Dose Synergetic Chemo‐Radiotherapy of Rheumatoid Arthritis; A Multifunctional Nanoreactor‐Induced Dual Inhibition of HSP70 Strategy for Enhancing Mild Photothermal/Chemodynamic Synergistic Tumor Therapy; Endogenous Melanin and Hydrogen‐Based Specific Activated Theranostics Nanoagents: A Novel Multi‐Treatment Paradigm for Rheumatoid Arthritis; Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy; In-situ GSH-responsive gas nanogenerator for active NIR-II FL/PA imaging and synergistic restoration the macrophage niche in rheumatoid arthritis; Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy; A novel bidirectional perfusion-like administered system for NIR-II fluorescence imaging precision diagnosis of bladder cancer; Multifunctional AuPd-cluster nanotheranostic agents with a cascade self-regulating redox tumor-microenvironment for dual-photodynamic synergized enzyme catalytic therapy; Endogenous nanoalbumin-based ROS cascade-amplification strategy for multi-treatment of rheumatoid arthritis. Representative work: Abstract Activatable fluorescence imaging in the second near‐infrared window (NIR‐II FL, 1000–1700 nm) is of great significance for accurate tumor diagnosis and targeting therapy. However, the clinical translation of most stimulus‐activated nanoprobes is severely restricted by insufficient tumor response and out‐of‐synchronization theranostic process. Herein, an intelligent nanofactory AUC‐GOx/Cel that possesses the “external supply, internal promotion” dual H 2 O 2 ‐amplification strategy for homologous activated tumor theranostic is designed. This nanofactory is constructed via a two‐step biomineralization method using Au‐doped Ag 2 S as a carrier for glucose oxidase (GOx) and celastrol, f The precise theranostics of rheumatoid arthritis (RA) remains a formidable challenge in clinical practice. Exploring novel applications of contemporary therapeutic approaches lik
Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy
Endogenous nanoalbumin-based ROS cascade-amplification strategy for multi-treatment of rheumatoid arthritis
Development of a novel macroscopic regulation and microscopic intervention mode nanosystem for osteoporosis treatment
A Novel Activatable Nanoradiosensitizer for Second Near‐Infrared Fluorescence Imaging‐Guided Safe‐Dose Synergetic Chemo‐Radiotherapy of Rheumatoid Arthritis
A Multifunctional Nanoreactor‐Induced Dual Inhibition of HSP70 Strategy for Enhancing Mild Photothermal/Chemodynamic Synergistic Tumor Therapy
Endogenous Melanin and Hydrogen‐Based Specific Activated Theranostics Nanoagents: A Novel Multi‐Treatment Paradigm for Rheumatoid Arthritis
In-situ GSH-responsive gas nanogenerator for active NIR-II FL/PA imaging and synergistic restoration the macrophage niche in rheumatoid arthritis
A novel bidirectional perfusion-like administered system for NIR-II fluorescence imaging precision diagnosis of bladder cancer
Dual H<sub>2</sub>O<sub>2</sub>‐Amplified Nanofactory for Simultaneous Self‐Enhanced NIR‐II Fluorescence Activation Imaging and Synergistic Tumor Therapy
Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence/photoacoustic imaging-guided precise synergistic therapy
Multifunctional AuPd-cluster nanotheranostic agents with a cascade self-regulating redox tumor-microenvironment for dual-photodynamic synergized enzyme catalytic therapy