Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Ubiquitin and proteasome pathways, Calpain Protease Function and Regulation, Mitochondrial Function and Pathology, and Lung Cancer Treatments and Mutations.
Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation
Ubiquitin proteasome system in immune regulation and therapeutics
GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase
NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
Germline BAP1 mutations induce a Warburg effect
The G protein–coupled receptor GPR31 promotes membrane association of KRAS
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress
Targeted gene inactivation reveals a functional role of calpain‐1 in platelet spreading