Area of research
Organic Chemistry · Immunology
Research interest
Research topics from publications: Visible‐Light‐Driven Metal‐Free C−H Functionalization: Access to New Bioactive Tetrahydroisoquinoline‐Butenolide Hybrids via Domino Amine Oxidation/Vinylogous Mannich Reaction**; Visible Light-driven Metal-free C–H Functionalization: Access to New Bioactive Tetrahydroisoquinoline-Butenolide Hybrids via Domino Amine Oxidation/Vinylogous Mannich Reaction. Representative work: Abstract An efficient metal‐free visible‐light‐driven two‐step domino reaction towards new bioactive tetrahydroisoquinoline‐butenolide hybrid compounds was developed for the first time. The combination of fluorescein as photosensitizer and thiourea as an additive was found to be the most effective way to promote an aerobic amine oxidation/vinylogous Mannich domino reaction sequence with yields up to 97 % for a broad substrate scope. Both experimental and computational evidence supported the crucial role of singlet oxygen in the developed C−H functionalization reaction. Furthermore, the data suggest that thiourea is essential due to its ability to act as an electron‐transfer mediator and/or s An efficient metal-free visible light-driven two-step domino reaction towards new bioactive tetrahydroisoquinoline-butenolide hybrid compounds was developed for the first time. Combination of fluorescein as photosensitizer and thiourea as an additive was found to be the most effective way to promote an aerobic amine oxidation/vinylogous Mannich domino reaction sequence with yields up to 97% for a broad substrate scope. While fluorescein without thiourea additive gave product in 84% yield, it was even observed that thiourea in absence of fluorescein is also able to promote formation of product with good yield of 75%, which is explained by a potential role of thiourea as an electron-transfer m