Area of research
Complementary and alternative medicine · Molecular Biology
Research interest
Research focused on Pyroptosis and Inflammasome, with related work in Quercetin, Macrophage, KEAP1. Notable publications include 'The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway', 'A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis', and 'Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction'.
Plaque erosion risk and <i>JAK2</i> V617F variant
Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA
Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells
Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting <scp>NRF2</scp> / <scp>GPX4</scp> pathway
Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway
Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder
Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the <scp>NF‐κB</scp> pathway and ameliorates atherosclerosis
Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients
Corrigendum to “Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway” [Free Radic. Biol. Med. 201 (2023) 76–88/15974]
A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis
Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction
Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT
Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis
Corrigendum to “A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis” [Redox Biol. 57 (2022) 102511]
The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway
Plaque Erosion: A Distinctive Pathological Mechanism of Acute Coronary Syndrome