Area of research
Molecular Biology · Genetics
Research interest
Research topics from publications: Halting Hypercaloric Feeding in Liver Chimeric Mice Rapidly Resolves Human Hepatocyte Steatosis. Representative work: Background and Aims: Hepatocyte steatosis in metabolic dysfunction-associated steatotic liver disease can change quickly based on the types and amounts of calories consumed. This study investigates how dietary changes affect steatosis resolution in human hepatocytes and whether patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants influence this process. Methods: ) hepatocytes were fed a Western diet (WD) and/or 10% sucrose water (10%S) to induce steatosis. After 4 weeks, mice either resumed chow to promote steatosis resolution or continued on WD or 10%S. Results: livers, including the retention of many polyunsaturated phosphatidylethanolamines and long-chain diglycerides.