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Joshua S. Bloom

Howard Hughes Medical Institute · US
Area of research
Molecular Biology · Genetics
Research interest
Research interests include Fungal and yeast genetics research, Genetic Mapping and Diversity in Plants and Animals, Bioinformatics and Genomic Networks, and CRISPR and Genetic Engineering.
h-index
30
citations
4,075
works
119
NIH funding
primary concept
email

Recent publications

Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
eLife 2025cited by 2position: middledoi
High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
eLife 2025cited by 1position: middledoi
High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
eLife 2025cited by 1position: middledoi
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells
Nature Communications 2024cited by 19position: middledoi
High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
eLife 2024cited by 13position: middledoi
Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
eLife 2024cited by 4position: middledoi
High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
eLife 2024cited by 2position: middledoi
Insufficient evidence for non-neutrality of synonymous mutations
Nature 2023cited by 25position: middledoi
Island-specific evolution of a sex-primed autosome in a sexual planarian
Nature 2022cited by 45position: middledoi
Genome-wide base editor screen identifies regulators of protein abundance in yeast
eLife 2022cited by 22position: middledoi
Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
PLoS Biology 2022cited by 2position: middledoi
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples
Nature Biomedical Engineering 2021cited by 75position: firstdoi
Whole-organism eQTL mapping at cellular resolution with single-cell sequencing
eLife 2021cited by 55position: middledoi
Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast
Science 2021cited by 52position: middledoi
Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos
PLoS Genetics 2021cited by 25position: middledoi
Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California
Clinical Infectious Diseases 2021cited by 16position: middledoi
Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity
JCI Insight 2020cited by 87position: middledoi
Rare variants contribute disproportionately to quantitative trait variation in yeast
eLife 2019cited by 103position: firstdoi
Analysis of the genetic basis of height in large Jewish nuclear families
PLoS Genetics 2019cited by 5position: middledoi
Genetics of trans-regulatory variation in gene expression
eLife 2018cited by 236position: middledoi
Highly parallel genome variant engineering with CRISPR–Cas9
Nature Genetics 2018cited by 100position: middledoi
The Genetic Basis of Mutation Rate Variation in Yeast
Genetics 2018cited by 59position: middledoi
Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses
Genetics 2018cited by 50position: middledoi
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast
Nature Genetics 2017cited by 163position: middledoi
Genetic variation in adaptability and pleiotropy in budding yeast
eLife 2017cited by 91position: middledoi
Genome to Phenome Mapping in Apple Using Historical Data
The Plant Genome 2016cited by 123position: middledoi
CRISPR-directed mitotic recombination enables genetic mapping without crosses
Science 2016cited by 107position: middledoi
Genetic interactions contribute less than additive effects to quantitative trait variation in yeast
Nature Communications 2015cited by 179position: firstdoi
A Powerful New Quantitative Genetics Platform, Combining<i>Caenorhabditis elegans</i>High-Throughput Fitness Assays with a Large Collection of Recombinant Strains
G3 Genes Genomes Genetics 2015cited by 126position: middledoi
Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae
PLoS Genetics 2015cited by 64position: middledoi

Grants

CDS&E: Accelerating Astrophysical Insight at Scale with Likelihood-Free Inference
NSF2206744$572,9262022–2026PIRePORTER
Collaborative Research: The Heavy Metal Survey: Stellar Metallicities and Chemical Abundance Patterns of Massive Galaxies out to z~2.3
NSF1909942$413,4472019–2024PIRePORTER
Collaborative Research: Community Planning for Scalable Cyberinfrastructure to Support Multi-Messenger Astrophysics
NSF1841612$29,5422018–2020PIRePORTER
BIGDATA: Small: DA: Classification Platform for Novel Scientific Insight on Time-Series Data
NSF1251274$733,5362013–2018PIRePORTER
Understanding and Exploiting the Dynamic Infrared Universe
NSF1009991$524,8032010–2013PIRePORTER
CDI-Type II: Real-time Classification of Massive Time-series Data Streams
NSF0941742$1,573,5502009–2013PIRePORTER
Collaborative Research: DDDAS-TMRP: Real-Time Astronomy with a Rapid-Response Telescope Grid
NSF0540352$135,3872005–2008PIRePORTER

Frequent collaborators

Leonid Kruglyak · Howard Hughes Medical Institute28 papers (2012–2025)Meru J. Sadhu · National Human Genome Research Institute8 papers (2015–2022)Sriram Kosuri · University of California, Los Angeles6 papers (2018–2025)James Boocock · Howard Hughes Medical Institute6 papers (2019–2025)Longhua Guo · University of California, Los Angeles4 papers (2021–2022) · 4 papers (2024–2025) · 4 papers (2024–2025) · 4 papers (2024–2025)Conor J Howard · Radiant Genomics (United States)4 papers (2024–2025)Laura Day · Howard Hughes Medical Institute4 papers (2016–2019) · 4 papers (2024–2025)Sebastian Treusch · Indiana University School of Medicine4 papers (2014–2019)Diane E. Dickel · Lawrence Berkeley National Laboratory4 papers (2024–2025)Aaron Cooper · Memorial Sloan Kettering Cancer Center4 papers (2024–2025)Leon Y Chan · University of California, Berkeley4 papers (2024–2025)Nathan S. Abell · Radiant Genomics (United States)4 papers (2024–2025)Giselle A. Uribe · Princeton University4 papers (2024–2025)Jonathan B Asfaha · Radiant Genomics (United States)4 papers (2024–2025)Eric M. Jones · Radiant Genomics (United States)4 papers (2024–2025)Andrew Liao · Rockefeller University4 papers (2024–2025)