Area of research
Molecular Biology · Astronomy and Astrophysics
Research interest
Research interests include DNA and Nucleic Acid Chemistry, RNA and protein synthesis mechanisms, Advanced biosensing and bioanalysis techniques, and Origins and Evolution of Life.
Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis
Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides
Template‐Directed Copying of RNA by Non‐enzymatic Ligation
A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides
Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation
Template‐Directed Copying of RNA by Non‐enzymatic Ligation
Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells
Non-enzymatic primer extension with strand displacement
Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage
DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates
Copying of Mixed-Sequence RNA Templates inside Model Protocells
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension
Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein
AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker
<i>O</i><sup>4</sup>‐Alkylated‐2‐Deoxyuridine Repair by <i>O</i><sup>6</sup>‐Alkylguanine DNA Alkyltransferase is Augmented by a C5‐Fluorine Modification